SESN2 and PRDX1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SESN2	PRDX1
Description		sestrin 2	peroxiredoxin 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Nucleotide-activated Protein Kinase Complex TORC2 Complex GATOR2 Complex Atg1/ULK1 Kinase Complex	Extracellular Space Nucleus Cytoplasm Cytosol Melanosome Extracellular Exosome
	Molecular Function	GDP-dissociation Inhibitor Activity Protein Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Sulfiredoxin Activity Leucine Binding	RNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Cadherin Binding
	Biological Process	Regulation Of Protein Phosphorylation Regulation Of Gluconeogenesis Fatty Acid Beta-oxidation Response To Glucose Positive Regulation Of Macroautophagy Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Mitochondrial DNA Metabolic Process Response To Insulin Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Response To Glucose Starvation Glucose Homeostasis Protein Kinase B Signaling Glucose Import Triglyceride Homeostasis Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Positive Regulation Of Protein Localization To Nucleus Regulation Of Response To Reactive Oxygen Species Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Negative Regulation Of TORC1 Signaling Positive Regulation Of Lipophagy Cellular Response To Leucine Starvation Regulation Of CAMP-dependent Protein Kinase Activity	Skeletal System Development Retina Homeostasis Response To Oxidative Stress Cell Population Proliferation Removal Of Superoxide Radicals Natural Killer Cell Activation Cellular Response To Stress Cellular Response To Oxidative Stress Hydrogen Peroxide Catabolic Process Leukocyte Activation Cell Redox Homeostasis
Pathways		TP53 Regulates Metabolic Genes Amino acids regulate mTORC1	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Serum uric acid levels ( 30993211) Urate levels ( 31578528)	Blood protein levels ( 28240269) Body mass index ( 26426971) Hemoglobin ( 32888494)
Interacting Genes		3 interacting genes: MDM2 PRDX1 RNF186	29 interacting genes: ABL1 ADH5 ADRB2 AXIN2 BTRC CALM1 CCR4 CLEC4G EGFR GAPDH IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 PTEN PTGER4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ
Entrez ID		83667	5052
HPRD ID		06378	01458
Ensembl ID		ENSG00000130766	ENSG00000117450
Uniprot IDs		P58004	A0A384NPQ2 Q06830
PDB IDs		5CUF 5DJ4 5T0N 6N0M	2RII 3HY2 4XCS
Enriched GO Terms of Interacting Partners?
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