EMC6 and AQP9

Data Source:
BioGRID (two hybrid)

		EMC6	AQP9
Description		ER membrane protein complex subunit 6	aquaporin 9
Image			No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane EMC Complex Integral Component Of Omegasome Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Membrane Insertase Activity	Amine Transmembrane Transporter Activity Purine Nucleobase Transmembrane Transporter Activity Pyrimidine Nucleobase Transmembrane Transporter Activity Water Transmembrane Transporter Activity Protein Binding Polyol Transmembrane Transporter Activity Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Urea Channel Activity Carboxylic Acid Transmembrane Transporter Activity
	Biological Process	Autophagosome Assembly Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Tail-anchored Membrane Protein Insertion Into ER Membrane	Water Transport Purine Nucleobase Transport Response To Osmotic Stress Excretion Response To Organic Substance Canalicular Bile Acid Transport Polyol Transport Glycerol Transport Amine Transport Pyrimidine Nucleobase Transport Water Homeostasis Response To Mercury Ion Carboxylic Acid Transport Cellular Response To CAMP Urea Transmembrane Transport Pyrimidine-containing Compound Transmembrane Transport Purine Nucleobase Transmembrane Transport Carboxylic Acid Transmembrane Transport
Pathways			Transport of glycerol from adipocytes to the liver by Aquaporins Passive transport by Aquaporins
Drugs
Diseases
GWAS			Glycine levels ( 30837465) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Ischemic stroke ( 26089329) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 23823483 22916037) Small cell lung carcinoma ( 28604730) Stroke ( 26089329) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		17 interacting genes: AQP6 AQP9 CD79A CREB3 EBP ERGIC3 FAM209A MFSD14B MMD MUC1 PDZK1IP1 SLC10A6 SLC39A2 SLC7A1 TLCD4 TMEM14B TMEM237	24 interacting genes: ADAM33 AIG1 APOD CCDC167 CLDN19 CPLX4 CTXN3 CXCL16 EMC6 FATE1 FXYD3 FZD7 GAST HHLA2 IGFBP5 LHFPL5 MIP PAEP SERINC1 SGPL1 SLC38A7 TF TMED9 TMEM109
Entrez ID		83460	366
HPRD ID		14529	04223
Ensembl ID		ENSG00000127774	ENSG00000103569
Uniprot IDs		Q9BV81	H0YK62 O43315
PDB IDs		6WW7 6Z3W
Enriched GO Terms of Interacting Partners?
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