CAPZA1 and CD2AP

Data Source:
HPRD (in vitro)

		CAPZA1	CD2AP
Description		capping actin protein of muscle Z-line subunit alpha 1	CD2 associated protein
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GO Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton F-actin Capping Protein Complex Actin Cytoskeleton Extracellular Exosome WASH Complex	Fibrillar Center Ruffle Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Filamentous Actin Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Cadherin Binding Actin Filament Binding	Vascular Endothelial Growth Factor Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Beta-catenin Binding Protein C-terminus Binding SH3 Domain Binding Identical Protein Binding Protein-containing Complex Binding Cadherin Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Actin Cytoskeleton Organization Cell Junction Assembly Interleukin-12-mediated Signaling Pathway Innate Immune Response Barbed-end Actin Filament Capping Protein-containing Complex Assembly	Substrate-dependent Cell Migration, Cell Extension Actin Filament Organization Cell Cycle Signal Transduction Vesicle Organization Negative Regulation Of Transforming Growth Factor Beta1 Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Protein Secretion Negative Regulation Of Small GTPase Mediated Signal Transduction Cell Division Protein-containing Complex Assembly Cell-cell Adhesion Positive Regulation Of Protein Localization To Nucleus Regulation Of Actin Cytoskeleton Reorganization
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Advanced glycosylation endproduct receptor signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production	Nephrin family interactions
Drugs
Diseases			Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Blood pressure ( 21572416) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 26390057 27841878 28739976 27618452 30487518) Height ( 25282103) Hypertension ( 30487518) Intraocular pressure ( 29617998 29785010) Mean arterial pressure ( 30487518) Mean platelet volume ( 32888494) Platelet count ( 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 28739976 27618452 30487518) Total cholesterol levels ( 30275531)	Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Family history of Alzheimer's disease ( 30617256) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Plasma homocysteine levels ( 26519441) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		7 interacting genes: ACTB CD2AP HSPA8 S100A1 S100B SH3KBP1 UCHL5	33 interacting genes: ARAP3 BCAR1 CAPZA1 CBL CBLB CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A SH3GL2 SOS1 SOS2 SRC UBC UBE2I WTIP YES1
Entrez ID		829	23607
HPRD ID		03347	05026
Ensembl ID		ENSG00000116489	ENSG00000198087
Uniprot IDs		P52907	Q9Y5K6
PDB IDs		1MQ1 1MWN	2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23 4WCI 4X1V
Enriched GO Terms of Interacting Partners?
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