CD2AP and HOXC11

Data Source:
BioGRID (two hybrid)

		CD2AP	HOXC11
Description		CD2 associated protein	homeobox C11
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Ruffle Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Filamentous Actin Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Vascular Endothelial Growth Factor Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Beta-catenin Binding Protein C-terminus Binding SH3 Domain Binding Identical Protein Binding Protein-containing Complex Binding Cadherin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Substrate-dependent Cell Migration, Cell Extension Actin Filament Organization Cell Cycle Signal Transduction Vesicle Organization Negative Regulation Of Transforming Growth Factor Beta1 Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Protein Secretion Negative Regulation Of Small GTPase Mediated Signal Transduction Cell Division Protein-containing Complex Assembly Cell-cell Adhesion Positive Regulation Of Protein Localization To Nucleus Regulation Of Actin Cytoskeleton Reorganization	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Endoderm Development Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development
Pathways		Nephrin family interactions
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Family history of Alzheimer's disease ( 30617256) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Plasma homocysteine levels ( 26519441) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		33 interacting genes: ARAP3 BCAR1 CAPZA1 CBL CBLB CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A SH3GL2 SOS1 SOS2 SRC UBC UBE2I WTIP YES1	16 interacting genes: CD2AP DNMT3L GTF2A1L GTF2H1 HDAC5 HTT IRF4 MEIS1 PSMA1 RCHY1 SMAD3 SOX8 SP1 STAT3 TBX21 TRIP10
Entrez ID		23607	3227
HPRD ID		05026	09275
Ensembl ID		ENSG00000198087	ENSG00000123388
Uniprot IDs		Q9Y5K6	O43248
PDB IDs		2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23 4WCI 4X1V
Enriched GO Terms of Interacting Partners?
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