MKKS and PLCB4

Data Source:
BioGRID (affinity chromatography technology)

		MKKS	PLCB4
Description		McKusick-Kaufman syndrome	phospholipase C beta 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Motile Cilium Kinociliary Basal Body	Nucleus Smooth Endoplasmic Reticulum Cytosol Postsynaptic Density Dendrite Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding ATP Binding Unfolded Protein Binding	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding
	Biological Process	Heart Looping Protein Folding Spermatid Development Determination Of Left/right Symmetry Heart Development Visual Perception Sensory Perception Of Smell Gonad Development Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Negative Regulation Of Actin Filament Polymerization Melanosome Transport Developmental Process Negative Regulation Of GTPase Activity Social Behavior Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Vasodilation Fat Cell Differentiation Photoreceptor Cell Maintenance Negative Regulation Of Blood Pressure Intracellular Transport Brain Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Chaperone-mediated Protein Complex Assembly Cartilage Development Regulation Of Stress Fiber Assembly Pigment Granule Aggregation In Cell Center Convergent Extension Involved In Gastrulation Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Face Development Non-motile Cilium Assembly	G Protein-coupled Receptor Signaling Pathway Lipid Catabolic Process Inositol Phosphate Metabolic Process Phosphatidylinositol-mediated Signaling Modulation Of Chemical Synaptic Transmission
Pathways		BBSome-mediated cargo-targeting to cilium	PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol G alpha (q) signalling events G alpha (q) signalling events
Drugs
Diseases		46,XX disorders of sex development (Other), including: Mullerian aplasia and hyperandrogenism; McKusick-Kaufman syndrome Bardet-Biedl syndrome (BBS)
GWAS			Daytime sleep phenotypes ( 27126917) Evening vs. morning chronotype (self-assessed) ( 32579418) Initial pursuit acceleration ( 29064472) Initial pursuit acceleration in psychotic disorders ( 29064472) Metabolite levels ( 23823483) Neutrophil count ( 20172861)
Interacting Genes		4 interacting genes: APP CDR2 PTN ZBED1	3 interacting genes: MEOX2 NLGN3 REL
Entrez ID		8195	5332
HPRD ID		05356	02885
Ensembl ID		ENSG00000125863	ENSG00000101333
Uniprot IDs		B7Z3W9 Q9NPJ1	Q15147
PDB IDs
Enriched GO Terms of Interacting Partners?
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