SF3A2 and LIN54

Data Source:
BioGRID (two hybrid)

		SF3A2	LIN54
Description		splicing factor 3a subunit 2	lin-54 DREAM MuvB core complex component
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2 SnRNP Nuclear Speck U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding	Regulatory Region Nucleic Acid Binding Minor Groove Of Adenine-thymine-rich DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Processing Positive Regulation Of Neuron Projection Development U2-type Prespliceosome Assembly	Regulation Of Transcription, DNA-templated Cell Cycle Nucleosome Positioning Regulation Of Cell Cycle
Pathways		mRNA Splicing - Major Pathway	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry
Drugs		Copper
Diseases
GWAS		Adult body size ( 32376654) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Myocardial infarction ( 24916648) Pulse pressure ( 26390057)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 30224653 30578418) Red blood cell count ( 29403010 32888494 27863252) Red cell distribution width ( 32888494) Systolic blood pressure ( 30578418) White blood cell count ( 32888494)
Interacting Genes		20 interacting genes: APBB1 ASPH BAIAP2 BEND2 CDC42 GRB2 HTATSF1 LIN54 NCK2 OSTF1 PRPF40A RETN SF3A1 SH3RF1 SMURF2 TCERG1 TFG TRIP10 VEZF1 YY1	7 interacting genes: BANP NFYC RB1 SF3A2 SP3 ZNF143 ZNF76
Entrez ID		8175	132660
HPRD ID		02877	13218
Ensembl ID		ENSG00000104897	ENSG00000189308
Uniprot IDs		Q05DF2 Q15428	Q6MZP7 Q7Z3G2
PDB IDs		5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6QX9 6Y53 6Y5Q	5FD3
Enriched GO Terms of Interacting Partners?
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