AKAP1 and PRKAR2B

Data Source:
HPRD (in vitro, in vivo)

		AKAP1	PRKAR2B
Description		A-kinase anchoring protein 1	protein kinase cAMP-dependent type II regulatory subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Membrane	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Neuronal Cell Body Dendritic Spine Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Glutamatergic Synapse
	Molecular Function	RNA Binding Protein Binding Protein Kinase A Regulatory Subunit Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Apoptotic Process Blood Coagulation Antiviral Innate Immune Response	G2/M Transition Of Mitotic Cell Cycle Renal Water Homeostasis Fatty Acid Metabolic Process Blood Coagulation Learning Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase A Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Regulation Of CAMP-mediated Signaling Modulation Of Chemical Synaptic Transmission Cellular Response To Glucagon Stimulus Response To Antipsychotic Drug Response To Clozapine Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Mitochondrial calcium ion transport Factors involved in megakaryocyte development and platelet production	PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs			Cyclic adenosine monophosphate
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Crohn's disease ( 26192919) Freckles ( 29895819) Inflammatory bowel disease ( 26192919) Male-pattern baldness ( 27182965)	Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)
Interacting Genes		12 interacting genes: AMY1A APP CAV1 CFAP91 DYSF MYCBP PPP1CA PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTPN21	18 interacting genes: AKAP1 AKAP10 AKAP11 AKAP14 AKAP4 AKAP5 AKAP7 AKAP9 C2orf88 CFAP91 ECM1 GNAI3 KIF5B LASP1 NBEA PAK1IP1 PRKACA TAF12
Entrez ID		8165	5577
HPRD ID		03905	01486
Ensembl ID		ENSG00000121057	ENSG00000005249
Uniprot IDs		A0A140VK05 B4DN86 Q92667	A0A024R712 B3KY43 P31323
PDB IDs
Enriched GO Terms of Interacting Partners?
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