PRKAR2B and AKAP5

Data Source:
HPRD (in vivo, in vitro)

		PRKAR2B	AKAP5
Description		protein kinase cAMP-dependent type II regulatory subunit beta	A-kinase anchoring protein 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Neuronal Cell Body Dendritic Spine Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Glutamatergic Synapse	Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Dendrite Membrane Dendritic Spine Membrane Raft Excitatory Synapse Postsynaptic Recycling Endosome
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Protein Binding Calmodulin Binding Adenylate Cyclase Binding SH3 Domain Binding Protein Phosphatase 2B Binding Beta-2 Adrenergic Receptor Binding Protein Kinase A Regulatory Subunit Binding Glutamate Receptor Binding GABA Receptor Binding Protein Kinase A Binding Molecular Adaptor Activity Scaffold Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Renal Water Homeostasis Fatty Acid Metabolic Process Blood Coagulation Learning Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase A Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Regulation Of CAMP-mediated Signaling Modulation Of Chemical Synaptic Transmission Cellular Response To Glucagon Stimulus Response To Antipsychotic Drug Response To Clozapine Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of CAMP-dependent Protein Kinase Activity	Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Chemical Synaptic Transmission Regulation Of Protein Kinase A Signaling Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Endosome To Plasma Membrane Protein Transport
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Trafficking of AMPA receptors ROBO receptors bind AKAP5 ROBO receptors bind AKAP5
Drugs		Cyclic adenosine monophosphate
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)
Interacting Genes		18 interacting genes: AKAP1 AKAP10 AKAP11 AKAP14 AKAP4 AKAP5 AKAP7 AKAP9 C2orf88 CFAP91 ECM1 GNAI3 KIF5B LASP1 NBEA PAK1IP1 PRKACA TAF12	21 interacting genes: ADRB2 CALM1 DLG1 DLG4 FOS GABRB1 GABRB3 IQGAP1 JUN KCNJ2 MDM2 PPP3CA PRKAR1A PRKAR2A PRKAR2B PRKCA RET ROPN1 ROPN1L TP53 TRPV1
Entrez ID		5577	9495
HPRD ID		01486	05255
Ensembl ID		ENSG00000005249	ENSG00000179841
Uniprot IDs		A0A024R712 B3KY43 P31323	P24588 Q6PG46
PDB IDs			2H9R 3LL8 5NIN
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?