CDADC1 and NUDT15

Data Source:
BioGRID (two hybrid)

		CDADC1	NUDT15
Description		cytidine and dCMP deaminase domain containing 1	nudix hydrolase 15
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytosol
	Molecular Function	Cytidine Deaminase Activity Zinc Ion Binding Protein Homodimerization Activity Importin-alpha Family Protein Binding	Protein Binding 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity Nucleoside-diphosphatase Activity NADH Pyrophosphatase Activity 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity DTTP Diphosphatase Activity Metal Ion Binding Nucleoside-triphosphate Diphosphatase Activity
	Biological Process	Cytidine Deamination DNA Cytosine Deamination	Mitotic Cell Cycle Response To Reactive Oxygen Species Purine Nucleotide Catabolic Process DGTP Catabolic Process Nucleobase-containing Small Molecule Catabolic Process DNA Protection Exogenous Drug Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Nucleoside Phosphate Catabolic Process
Pathways			Phosphate bond hydrolysis by NUDT proteins
Drugs
Diseases
GWAS			Estimated glomerular filtration rate ( 31015462) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 27558924 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes			2 interacting genes: GABARAPL2 SRD5A3
Entrez ID		81602	55270
HPRD ID		16693	14848
Ensembl ID		ENSG00000102543	ENSG00000136159
Uniprot IDs		Q9BWV3	Q9NV35
PDB IDs			5BON 5LPG 6T5J
Enriched GO Terms of Interacting Partners?
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