NUDT15 and SRD5A3

Data Source:
BioGRID (two hybrid)

		NUDT15	SRD5A3
Description		nudix hydrolase 15	steroid 5 alpha-reductase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity Nucleoside-diphosphatase Activity NADH Pyrophosphatase Activity 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity DTTP Diphosphatase Activity Metal Ion Binding Nucleoside-triphosphate Diphosphatase Activity	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Cholestenone 5-alpha-reductase Activity Polyprenol Reductase Activity
	Biological Process	Mitotic Cell Cycle Response To Reactive Oxygen Species Purine Nucleotide Catabolic Process DGTP Catabolic Process Nucleobase-containing Small Molecule Catabolic Process DNA Protection Exogenous Drug Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Nucleoside Phosphate Catabolic Process	Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Androgen Biosynthetic Process Polyprenol Catabolic Process Dolichol Metabolic Process Dolichol Biosynthetic Process
Pathways		Phosphate bond hydrolysis by NUDT proteins	Androgen biosynthesis Synthesis of Dolichyl-phosphate Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ
Drugs			Spironolactone
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 27558924 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) PR interval ( 32439900) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		2 interacting genes: GABARAPL2 SRD5A3	2 interacting genes: ADK NUDT15
Entrez ID		55270	79644
HPRD ID		14848	07825
Ensembl ID		ENSG00000136159	ENSG00000128039
Uniprot IDs		Q9NV35	Q9H8P0
PDB IDs		5BON 5LPG 6T5J
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?