SLC7A5 and TUBB3

Data Source:
BioGRID (pull down, affinity chromatography technology)

		SLC7A5	TUBB3
Description		solute carrier family 7 member 5	tubulin beta 3 class III
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GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Plasma Membrane Basal Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Microvillus Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome External Side Of Apical Plasma Membrane Amino Acid Transport Complex	Nucleus Cytoplasm Microtubule Lamellipodium Filopodium Axon Dendrite Growth Cone Extracellular Exosome
	Molecular Function	Protein Binding Amino Acid Transmembrane Transporter Activity Aromatic Amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity L-tryptophan Transmembrane Transporter Activity Thyroid Hormone Transmembrane Transporter Activity Peptide Antigen Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Netrin Receptor Binding
	Biological Process	Positive Regulation Of Cytokine Production Involved In Immune Response Amino Acid Transmembrane Transport Negative Regulation Of Gene Expression Neutral Amino Acid Transport Phenylalanine Transport Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-4 Production Xenobiotic Transport Leukocyte Migration Thyroid Hormone Transport Amino Acid Import Across Plasma Membrane Leucine Import Across Plasma Membrane Transport Across Blood-brain Barrier L-alpha-amino Acid Transmembrane Transport L-leucine Import Across Plasma Membrane L-tryptophan Transmembrane Transport	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Axon Guidance Netrin-activated Signaling Pathway Dorsal Root Ganglion Development
Pathways		Basigin interactions Amino acid transport across the plasma membrane Tryptophan catabolism	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs			Epothilone D Patupilone Ixabepilone CYT997 ZEN-012 Phenethyl Isothiocyanate
Diseases			Congenital fibrosis of the extraocular muscles (CFEOM)
GWAS		Blood metabolite levels ( 24816252) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494)	Brain morphology (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Left-handedness ( 32989287) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Squamous cell carcinoma ( 31174203)
Interacting Genes		1 interacting genes: SLC3A2	34 interacting genes: ABCC2 ANXA7 ARHGEF7 CAMSAP3 CDC42 CDKN1A DDX39B DUX4 EEF1G GABARAP GZMK HEXD INSM1 KHDRBS1 LAPTM4A LIG1 LINC01554 MAP7D3 MAPT MRPL28 MTCL1 MTDH PHIP PLK1 RCC1 RILPL2 ROBO1 SEL1L3 SMN1 SPTSSA TERF1 TF TK1 TPTE
Entrez ID		8140	10381
HPRD ID		02552	04044
Ensembl ID		ENSG00000103257	ENSG00000258947
Uniprot IDs		Q01650	Q13509 Q53G92
PDB IDs		6IRS 6IRT 6JMQ	5IJ0 5IJ9 5JCO 6E7B 6S8L 6WSL
Enriched GO Terms of Interacting Partners?
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