IFT88 and MAP4K5

Data Source:
BioGRID (affinity chromatography technology)

		IFT88	MAP4K5
Description		intraflagellar transport 88	mitogen-activated protein kinase kinase kinase kinase 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cilium Intraciliary Transport Particle B Motile Cilium Ciliary Basal Body Sperm Flagellum Ciliary Tip Ciliary Base Non-motile Cilium	Cytoplasm
	Molecular Function	Protein Binding Kinesin Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Kidney Development Intraciliary Transport Involved In Cilium Assembly Intraciliary Transport Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Regulation Of Cilium Assembly Non-motile Cilium Assembly Regulation Of Autophagosome Assembly	Activation Of MAPKKK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Intracellular Signal Transduction
Pathways		Hedgehog 'off' state Intraflagellar transport Intraflagellar transport Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs			Fostamatinib
Diseases
GWAS		Coronary artery calcification ( 23870195) Dental caries ( 23064961) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Sulfasalazine-induced agranulocytosis ( 28762467)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cognitive performance ( 20125193) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 32888494) Periodontal disease-related phenotype (Socransky) ( 24347629) Red blood cell count ( 32888494)
Interacting Genes		10 interacting genes: CAPN7 CCDC120 EEF2KMT EML2 FBXO7 ITPKB MSRB1 PRRC2A RPGR SMARCE1	13 interacting genes: ABL1 BCR COPS5 CRK CRKL GRB2 HCK NEDD4 SETDB1 SMURF1 TANK TRAF2 ZNF440
Entrez ID		8100	11183
HPRD ID		09000	05374
Ensembl ID		ENSG00000032742	ENSG00000012983
Uniprot IDs		A0A140VJL7 B3KX42 Q13099	B3KWC4 Q9Y4K4
PDB IDs
Enriched GO Terms of Interacting Partners?
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