HMGA2 and NFKB1

Data Source:
HPRD (in vitro)

		HMGA2	NFKB1
Description		high mobility group AT-hook 2	nuclear factor kappa B subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm Protein-DNA Complex Senescence-associated Heterochromatin Focus SMAD Protein Complex	Chromatin Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol I-kappaB/NF-kappaB Complex Secretory Granule Lumen Specific Granule Lumen
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Transcription Factor Binding DNA Binding, Bending Nucleosomal DNA Binding CAMP Response Element Binding MH2 Domain Binding MH1 Domain Binding SMAD Binding 5'-deoxyribose-5-phosphate Lyase Activity C2H2 Zinc Finger Domain Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Actinin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition Chondrocyte Differentiation Mesodermal-endodermal Cell Signaling Base-excision Repair Chromatin Organization Regulation Of Transcription, DNA-templated Mitotic G2 DNA Damage Checkpoint Multicellular Organism Development Response To Virus Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Chromosome Condensation Chromosome Breakage Heterochromatin Assembly Histone H2A-S139 Phosphorylation Senescence-associated Heterochromatin Focus Assembly Endodermal Cell Differentiation Chondrocyte Proliferation Regulation Of Growth DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation By Host Of Viral Transcription Fat Cell Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Mesodermal Cell Differentiation Mesenchymal Cell Differentiation Stem Cell Differentiation Cell Division Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Protein Serine/threonine Kinase Activity Oncogene-induced Cell Senescence Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Cellular Response To X-ray Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cellular Response To Drug	Negative Regulation Of Transcription By RNA Polymerase II Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Inflammatory Response Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Negative Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Vitamin D Biosynthetic Process Membrane Protein Intracellular Domain Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cholesterol Transport Positive Regulation Of Type I Interferon Production Negative Regulation Of Interleukin-12 Production Response To Muscle Stretch Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To DsRNA Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Hyaluronan Biosynthetic Process Cellular Response To Angiotensin Positive Regulation Of MiRNA Metabolic Process
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines Transcriptional regulation of white adipocyte differentiation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway MAP3K8 (TPL2)-dependent MAPK1/3 activation Neutrophil degranulation The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation HCMV Early Events Purinergic signaling in leishmaniasis infection
Drugs			Donepezil Pseudoephedrine Thalidomide Pranlukast HE3286 P54 NOX-700 SGN-30 Custirsen NF-kappaB Decoy Andrographolide Triflusal Glycyrrhizic acid Fish oil SC-236
Diseases
GWAS		Adverse response to drug ( 30420678) Aortic root size ( 19584346) Axial length ( 24144296) Birth length ( 25281659) Birth weight ( 23202124 31043758 27680694) Body size at age 10 ( 32376654) Brain structure ( 22504417) Childhood body mass index ( 33045005) Chin dimples ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cortical surface area (global PC1) ( 32198502) Head circumference (infant) ( 22504419) Heart rate response to exercise ( 29769521) Heel bone mineral density ( 30598549) Height ( 21998595 28552196 20881960 22021425 25282103 25429064 19343178 23563607 31562340 18391950 18391951 18391952 20397748 17767157) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Late-onset Alzheimer's disease ( 27770636) Medication use (drugs used in diabetes) ( 31015401) Neutrophil count ( 32888494) Offspring birth weight ( 31043758) Permanent tooth development ( 21931568) Plateletcrit ( 32888494) Polycystic ovary syndrome ( 22885925) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 31928498) Triglyceride levels ( 32203549) Type 2 diabetes ( 22885922 24509480 30054458 26961502 29358691 25102180 30297969 32499647 20581827 28869590) Type 2 diabetes nephropathy ( 21150874) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Youthful appearance (self-reported) ( 32339537)	Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Basophil percentage of white cells ( 32888494) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Copper levels ( 26025379) Creatinine levels ( 29124443) Crohn's disease ( 28067908) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 29124443 30604766) Glomerular filtration rate (creatinine) ( 26831199) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Membranous nephropathy ( 32231244) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 21833088) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483 23000144 21399635 26394269 28062665 30643196) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 27992413) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia (treatment resistant) ( 22479419) Serum total protein level ( 29403010) Serum uric acid levels ( 29124443) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 31672989 30247649) Tonsillectomy ( 27182965 28928442) Ulcerative colitis ( 23128233) White blood cell count ( 32888494)
Interacting Genes		21 interacting genes: APEX1 CDK1 CSNK2A1 CSNK2A2 E4F1 MDM2 NFKB1 NPM1 PA2G4 PCBP2 PIAS3 PRKCA PRMT6 PSIP1 PTBP1 RB1 RELA SMAD3 SYNCRIP TP53 XRCC6	104 interacting genes: ABCC2 APBB2 AR ATF3 BCL3 BRCA1 BTRC CDK9 CEBPB CFLAR CHUK COPB2 COPS5 CTNNB1 DNMT3L E2F1 ECSIT ELF1 ELF3 ESR1 ETS1 FBXW11 FOS G3BP2 GLUL GSK3B HDAC1 HMGA1 HMGA2 HMGB1 HSPA4 IKBKB IKBKG IL2RA IRF1 IRF2 IRF8 IRF9 ITGB3BP KAT5 KLF5 KPNA3 LYL1 MAP3K8 MEN1 MTPN NCOA1 NCOA6 NCOR2 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIZ NFRKB NKRF NOTCH1 NR3C1 NR4A1 PALS2 PARP1 PCBD1 PDCD11 PELP1 PLD3 PML PPARG PPP4C PRKACA PSMD10 REL RELA RELB RGS14 RIPK1 RPS3 RSF1 RXRA SERPINA3 SF1 SIN3A SP1 SPAG9 SPI1 SPPL2A SRF STAT3 STAT6 TAB2 TFAP2A TNFSF11 TNIP1 TNIP2 TP53BP1 TP53BP2 TRIP4 TSC22D3 TXN UBE2D3 UBE2K UNC5CL YWHAQ YY1 ZBTB9
Entrez ID		8091	4790
HPRD ID		02827	01238
Ensembl ID		ENSG00000149948	ENSG00000109320
Uniprot IDs		F5H2A4 F5H6H0 P52926 Q1M183	P19838
PDB IDs			1MDI 1MDJ 1MDK 1NFI 1SVC 2DBF 2O61 3GUT
Enriched GO Terms of Interacting Partners?
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