NFKB1 and KLF5

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		NFKB1	KLF5
Description		nuclear factor kappa B subunit 1	Kruppel like factor 5
Image
GO Annotations	Cellular Component	Chromatin Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol I-kappaB/NF-kappaB Complex Secretory Granule Lumen Specific Granule Lumen	Chromatin Nucleoplasm Transcription Regulator Complex Golgi Apparatus Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Actinin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding MRF Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Inflammatory Response Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Negative Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Vitamin D Biosynthetic Process Membrane Protein Intracellular Domain Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cholesterol Transport Positive Regulation Of Type I Interferon Production Negative Regulation Of Interleukin-12 Production Response To Muscle Stretch Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To DsRNA Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Hyaluronan Biosynthetic Process Cellular Response To Angiotensin Positive Regulation Of MiRNA Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Skeletal Muscle Satellite Cell Differentiation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Myotube Differentiation Involved In Skeletal Muscle Regeneration Microvillus Assembly Regulation Of Microvillus Assembly Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Intestinal Epithelial Cell Development Positive Regulation Of Transcription By Transcription Factor Localization Cellular Response To Organic Cyclic Compound Cell-cell Signaling Via Exosome Cellular Response To Peptide Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Cellular Response To Leukemia Inhibitory Factor
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines Transcriptional regulation of white adipocyte differentiation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway MAP3K8 (TPL2)-dependent MAPK1/3 activation Neutrophil degranulation The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation HCMV Early Events Purinergic signaling in leishmaniasis infection	Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis
Drugs		Donepezil Pseudoephedrine Thalidomide Pranlukast HE3286 P54 NOX-700 SGN-30 Custirsen NF-kappaB Decoy Andrographolide Triflusal Glycyrrhizic acid Fish oil SC-236
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Basophil percentage of white cells ( 32888494) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Copper levels ( 26025379) Creatinine levels ( 29124443) Crohn's disease ( 28067908) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 29124443 30604766) Glomerular filtration rate (creatinine) ( 26831199) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Membranous nephropathy ( 32231244) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 21833088) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483 23000144 21399635 26394269 28062665 30643196) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 27992413) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia (treatment resistant) ( 22479419) Serum total protein level ( 29403010) Serum uric acid levels ( 29124443) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 31672989 30247649) Tonsillectomy ( 27182965 28928442) Ulcerative colitis ( 23128233) White blood cell count ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29679657) Blood urea nitrogen levels ( 31152163) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast Cancer in BRCA1 mutation carriers ( 29058716) Chronotype ( 30696823) Colorectal cancer ( 30529582) Colorectal cancer or advanced adenoma ( 30510241) Creatine kinase levels ( 29403010) Endometrial cancer ( 30093612 27008869) Endometrial cancer (endometrioid histology) ( 30093612) Intraocular pressure ( 29785010 31959993) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Pancreatic cancer ( 29422604 20101243 26098869 25086665) Prostate cancer ( 31562322 26443449) Systolic blood pressure ( 30224653) Type 2 diabetes ( 25760438)
Interacting Genes		104 interacting genes: ABCC2 APBB2 AR ATF3 BCL3 BRCA1 BTRC CDK9 CEBPB CFLAR CHUK COPB2 COPS5 CTNNB1 DNMT3L E2F1 ECSIT ELF1 ELF3 ESR1 ETS1 FBXW11 FOS G3BP2 GLUL GSK3B HDAC1 HMGA1 HMGA2 HMGB1 HSPA4 IKBKB IKBKG IL2RA IRF1 IRF2 IRF8 IRF9 ITGB3BP KAT5 KLF5 KPNA3 LYL1 MAP3K8 MEN1 MTPN NCOA1 NCOA6 NCOR2 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIZ NFRKB NKRF NOTCH1 NR3C1 NR4A1 PALS2 PARP1 PCBD1 PDCD11 PELP1 PLD3 PML PPARG PPP4C PRKACA PSMD10 REL RELA RELB RGS14 RIPK1 RPS3 RSF1 RXRA SERPINA3 SF1 SIN3A SP1 SPAG9 SPI1 SPPL2A SRF STAT3 STAT6 TAB2 TFAP2A TNFSF11 TNIP1 TNIP2 TP53BP1 TP53BP2 TRIP4 TSC22D3 TXN UBE2D3 UBE2K UNC5CL YWHAQ YY1 ZBTB9	27 interacting genes: ANP32B ATXN3L BAP1 CREBBP EP300 ESR1 FBXW7 GSK3B GTF2B GTF2E2 GTF2F2 HDAC1 JUN NCOR1 NCOR2 NFKB1 PARP1 PPARG PRKCA PRKCD RARA RXRA SET SMURF2 TBP UBE2I WWP1
Entrez ID		4790	688
HPRD ID		01238	04212
Ensembl ID		ENSG00000109320	ENSG00000102554
Uniprot IDs		P19838	Q13887 Q5T6X2
PDB IDs		1MDI 1MDJ 1MDK 1NFI 1SVC 2DBF 2O61 3GUT	2EBT
Enriched GO Terms of Interacting Partners?
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