GRIP2 and GRIA3

Data Source:
HPRD (two hybrid)

		GRIP2	GRIA3
Description		glutamate receptor interacting protein 2	glutamate ionotropic receptor AMPA type subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Plasma Membrane Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Dendritic Spine Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse
	Molecular Function	Signaling Receptor Complex Adaptor Activity	Amyloid-beta Binding AMPA Glutamate Receptor Activity Ligand-gated Ion Channel Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane	Glutamate Receptor Signaling Pathway Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Potential Regulation Of NMDA Receptor Activity
Pathways		Trafficking of GluR2-containing AMPA receptors	Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules
Drugs			Glutamic acid Butabarbital Ethanol Lithium cation Aniracetam Talampanel CX-717 Fluciclovine (18F) Lithium citrate Lithium succinate Lithium carbonate
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Cognitive performance ( 19734545) SjÃ¶gren's syndrome ( 28076899)	Mortality in sepsis ( 27639821)
Interacting Genes		4 interacting genes: CSPG4 GFI1B GRIA2 GRIA3	11 interacting genes: ADRB2 GRIA2 GRIP1 GRIP2 GZMB LYN NSF PICK1 PPM1G SDCBP SQSTM1
Entrez ID		80852	2892
HPRD ID		18994	02378
Ensembl ID		ENSG00000144596	ENSG00000125675
Uniprot IDs		Q9C0E4	P42263 Q17R51 Q5XKG2
PDB IDs		1V62 1X5R
Enriched GO Terms of Interacting Partners?
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