GRIA3 and GRIP2

Data Source:
HPRD (two hybrid)

		GRIA3	GRIP2
Description		glutamate ionotropic receptor AMPA type subunit 3	glutamate receptor interacting protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Dendritic Spine Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse	Cytosol Plasma Membrane
	Molecular Function	Amyloid-beta Binding AMPA Glutamate Receptor Activity Ligand-gated Ion Channel Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Signaling Receptor Complex Adaptor Activity
	Biological Process	Glutamate Receptor Signaling Pathway Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Potential Regulation Of NMDA Receptor Activity	Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane
Pathways		Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules	Trafficking of GluR2-containing AMPA receptors
Drugs		Glutamic acid Butabarbital Ethanol Lithium cation Aniracetam Talampanel CX-717 Fluciclovine (18F) Lithium citrate Lithium succinate Lithium carbonate
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Mortality in sepsis ( 27639821)	Cognitive performance ( 19734545) SjÃ¶gren's syndrome ( 28076899)
Interacting Genes		11 interacting genes: ADRB2 GRIA2 GRIP1 GRIP2 GZMB LYN NSF PICK1 PPM1G SDCBP SQSTM1	4 interacting genes: CSPG4 GFI1B GRIA2 GRIA3
Entrez ID		2892	80852
HPRD ID		02378	18994
Ensembl ID		ENSG00000125675	ENSG00000144596
Uniprot IDs		P42263 Q17R51 Q5XKG2	Q9C0E4
PDB IDs			1V62 1X5R
Enriched GO Terms of Interacting Partners?
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