DNAJC5 and ERC1

Data Source:
BioGRID (fluorescent resonance energy transfer)

		DNAJC5	ERC1
Description		DnaJ heat shock protein family (Hsp40) member C5	ELKS/RAB6-interacting/CAST family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Anchored Component Of Membrane Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Anchored Component Of Synaptic Vesicle Membrane	Golgi Membrane Cytoplasm Centrosome IkappaB Kinase Complex Ciliary Basal Body Presynaptic Membrane Synapse Cytoskeleton Of Presynaptic Active Zone
	Molecular Function	Protein Binding ATP-dependent Protein Binding	Protein Binding PDZ Domain Binding Small GTPase Binding Leucine Zipper Domain Binding Cadherin Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Exocytosis Neurotransmitter Secretion Synaptic Vesicle Exocytosis Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Chaperone-mediated Protein Folding Regulation Of Synaptic Vesicle Cycle	Regulation Of Transcription, DNA-templated I-kappaB Phosphorylation Neuromuscular Synaptic Transmission Multicellular Organism Development Protein Transport Retrograde Transport, Endosome To Golgi Negative Regulation Of Apoptotic Process Regulation Of Synaptic Plasticity Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Neutrophil degranulation GABA synthesis, release, reuptake and degradation
Drugs
Diseases
GWAS		Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)	Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Body mass index ( 26426971) Forehead morphology ( 29921221) Height ( 29782485) Lumbar spine bone mineral density ( 22504420) Medial temporal lobe substructure volumes ( 32768867)
Interacting Genes		56 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CASK CD2 CFTR CGB5 CLCN3 EFNB1 ERC1 FAS FCHO1 GRM8 HBA2 HGS KHDC4 LIN7A LIN7C NECAP1 NRXN3 NUMB PPFIA1 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP1 SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 STX7 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7	9 interacting genes: APP DNAJC5 ITSN2 PPFIA1 RAB6A RAB6B RIMS1 SRPK2 YWHAG
Entrez ID		80331	23085
HPRD ID		08539	06181
Ensembl ID		ENSG00000101152	ENSG00000082805
Uniprot IDs		Q6AHX3 Q9H3Z4	G8JLD3 Q8IUD2 X6RLX0
PDB IDs		2N04 2N05
Enriched GO Terms of Interacting Partners?
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