NCOA4 and RNF14

Data Source:
HPRD (in vivo, in vitro)

		NCOA4	RNF14
Description		nuclear receptor coactivator 4	ring finger protein 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Autolysosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Activity	Transcription Coactivator Activity Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Androgen Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Targeting To Lysosome Cellular Iron Ion Homeostasis Male Gonad Development Response To Hormone Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Cellular Response To Estrogen Stimulus Cellular Response To Testosterone Stimulus	Protein Polyubiquitination Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Signal Transduction Protein Ubiquitination Protein Phosphopantetheinylation Androgen Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Androgen Receptor Signaling Pathway
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Thyroid cancer
GWAS		Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Apolipoprotein A1 levels ( 32203549) Mean corpuscular hemoglobin ( 29403010 20139978) Mean corpuscular volume ( 29403010 20139978) Red blood cell count ( 29403010)	Asthma ( 31959851) Superior temporal gyrus volume ( 31530798)
Interacting Genes		12 interacting genes: AKT1 AR ATXN2 ESR1 GTF2B KAT2B MID2 NR3C1 PPARG RNF14 RXRA VDR	23 interacting genes: AR DACH1 ESR1 HNF1A HNRNPA1 NCOA4 NR3C1 PHF7 TAGLN TENT5A TNFAIP3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2U UBE2V1 UBE2W VDR
Entrez ID		8031	9604
HPRD ID		03584	05745
Ensembl ID		ENSG00000266412	ENSG00000013561
Uniprot IDs		A0A024QZI5 B2R5V0 Q13772 Q96E88	B7Z229 Q9UBS8
PDB IDs		1T5Z
Enriched GO Terms of Interacting Partners?
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