MLLT10 and SS18

Data Source:
HPRD (two hybrid, in vivo)

		MLLT10	SS18
Description		MLLT10 histone lysine methyltransferase DOT1L cofactor	SS18 subunit of BAF chromatin remodeling complex
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Protein-containing Complex	Nucleus Microtubule Cytoskeleton SWI/SNF Complex NpBAF Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Nucleosome Binding Histone Binding Metal Ion Binding	Protein Binding Nuclear Receptor Coactivator Activity
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II	Microtubule Cytoskeleton Organization Cell Morphogenesis Intracellular Signal Transduction Response To Drug Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Neuronal Stem Cell Population Maintenance
Pathways
Drugs
Diseases			Synovial sarcoma
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 23535729) Epithelial ovarian cancer ( 25581431) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Gallstone disease ( 30504769) Hand grip strength ( 29691431) Lateral ventricular volume in normal aging ( 30258056) Meningioma ( 21804547) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) Multisite chronic pain ( 31194737) Oily fish consumption ( 32066663) Ovarian cancer ( 23535730) Pork consumption ( 32066663) Raw vegetable consumption ( 32066663) Subcutaneous adipose tissue ( 26480920) Urinary albumin-to-creatinine ratio ( 31630189) Urinary sodium excretion ( 31409800)	Autoimmune thyroid disease ( 32581359) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Mean corpuscular hemoglobin ( 32888494) Nickel levels ( 26025379) Obesity-related traits ( 23251661) Periodontitis (Mean PAL) ( 24024966) QT interval (sulfonylurea treatment interaction) ( 27958378) Rhegmatogenous retinal detachment ( 23585552) Systemic juvenile idiopathic arthritis ( 27927641) Toenail selenium levels ( 25343990)
Interacting Genes		15 interacting genes: DISC1 DOT1L FOXI1 HNF1B HPCA MLLT1 NCALD NDEL1 POU2F1 POU6F2 RBPMS RGPD5 SS18 VEZF1 YEATS4	9 interacting genes: EP300 FUS GRB2 H3-3A MLLT10 NFKBID RBM14 SMARCA2 SMARCA4
Entrez ID		8028	6760
HPRD ID		03874	02559
Ensembl ID		ENSG00000078403	ENSG00000141380
Uniprot IDs		P55197 Q59EQ6 Q6N002	A0A024RC40 B4DLD3 B4DR34 B4E2J6 Q15532 Q4VAX0
PDB IDs		5DAG 5DAH 6CKN 6CKO 6JN2
Enriched GO Terms of Interacting Partners?
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