CEP63 and TXLNA

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		CEP63	TXLNA
Description		centrosomal protein 63	taxilin alpha
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Centrosome Centriole Cytosol	Extracellular Region Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding	Protein Binding Syntaxin Binding
	Biological Process	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Spindle Assembly Cell Division Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation	Exocytosis Cytokine-mediated Signaling Pathway B Cell Activation
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Other interleukin signaling
Drugs
Diseases
GWAS		Height ( 18391952) Late-onset Alzheimer's disease ( 27770636) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		66 interacting genes: ALOX5 ARFIP2 ARNT2 BFSP2 BRPF1 CAMKK2 CAPN7 CCDC14 CCDC187 CCHCR1 CCNI CDK1 CEP57 CEP57L1 CWF19L2 DAXX DISC1 DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 FEM1C GSE1 HAUS1 HGS INTS6L KANK2 KXD1 MACF1 MBIP MNS1 NCOR2 NDC80 NDEL1 NXT2 PCNX4 PIBF1 POLR3C PPP1R13B PPP4R1 RCOR3 ROGDI SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TBC1D15 TBC1D22B TSG101 TSGA10IP TSHZ3 TXLNA TXLNB USHBP1 USP2 ZCCHC10 ZNF148 ZNF250 ZNF774	95 interacting genes: AXIN2 AZI2 BIN3 BRCA1 BRMS1L BTF3 BTF3L4 CBY2 CCDC112 CCDC136 CCDC146 CCDC196 CCDC33 CCDC57 CCHCR1 CDC5L CDR2 CEP44 CEP57 CEP57L1 CEP63 CFAP53 DEUP1 DMAP1 DTNB EIF4ENIF1 EPN2 FAM81A FAM9A GAS8 GOLGA2 GOLGA6A GORASP2 HAUS3 HYPK IKBKG KANK2 KIAA1328 KRT13 KRT15 KRT20 KRT24 KRT27 KRT31 KRT34 KRT35 KRT36 KRT38 KRT40 KRT75 LCA5 LZTS1 MBIP MCC MED4 MEOX1 MEOX2 MIS18A NACA NDC80 NKAPD1 NMI NSMCE2 NUP62 OLIG2 PIAS2 PPFIA1 PPP1R13B PRDM16 PRPF3 RASSF8 RCOR3 RINT1 SIKE1 SMARCE1 SNF8 SORBS3 SREK1 STMN2 STX1A STX1B STX3 STX4 TBC1D1 TCL1A TFIP11 TNIP1 TP53BP2 TTC33 TXLNB USHBP1 UTP14C VPS52 WASHC1 WASHC3
Entrez ID		80254	200081
HPRD ID		07826	09408
Ensembl ID		ENSG00000182923	ENSG00000084652
Uniprot IDs		Q96MT8	P40222
PDB IDs		6CSU 6CSV
Enriched GO Terms of Interacting Partners?
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