FBXL7 and TBC1D5

Data Source:
BioGRID (two hybrid)

		FBXL7	TBC1D5
Description		F-box and leucine rich repeat protein 7	TBC1 domain family member 5
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Centrosome Cytosol SCF Ubiquitin Ligase Complex	Autophagosome Golgi Apparatus Cytosol Endosome Membrane AP-2 Adaptor Complex Retromer Complex Intracellular Membrane-bounded Organelle Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding AP-2 Adaptor Complex Binding Protein-containing Complex Binding Retromer Complex Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process SCF Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cell Division	Positive Regulation Of Receptor Internalization Intracellular Protein Transport Autophagy Macroautophagy Retrograde Transport, Endosome To Golgi Response To Starvation Activation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Alzheimer's disease (late onset) ( 26339675) Asthma (corticosteroid response) ( 24486069) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diisocyanate-induced asthma ( 25918132) Economic and political preferences (feminism/equality) ( 22566634) Obesity-related traits ( 23251661) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Response to fenofibrate (total cholesterol levels) ( 27002377) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Visceral fat ( 22589738)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Mean platelet volume ( 32888494 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Parkinson's disease ( 32201043) Platelet count ( 32888494 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 32888494 27863252) Schizophrenia ( 28991256 25056061 29483656) Self-reported risk-taking behaviour ( 30271922) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: APP BIRC5 FBXL18 FCHO1 TBC1D5	10 interacting genes: AP2M1 ATXN1 CHIA EIF1AD FBXL7 GABARAPL1 GABARAPL2 MAP1LC3A UBC ZBTB25
Entrez ID		23194	9779
HPRD ID		05740	10262
Ensembl ID		ENSG00000183580	ENSG00000131374
Uniprot IDs		Q9UJT9	B9A6K1 Q92609
PDB IDs			5GTU
Enriched GO Terms of Interacting Partners?
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