DHDDS and VRK2

Data Source:
BioGRID (two hybrid)

		DHDDS	VRK2
Description		dehydrodolichyl diphosphate synthase subunit	VRK serine/threonine kinase 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Dehydrodolichyl Diphosphate Synthase Complex	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane Protein-containing Complex
	Molecular Function	Polyprenyltransferase Activity Protein Binding Dehydrodolichyl Diphosphate Synthase Activity Metal Ion Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Domain Specific Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Dolichyl Diphosphate Biosynthetic Process Polyprenol Biosynthetic Process	Protein Phosphorylation Viral Process Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Synthesis of Dolichyl-phosphate Defective DHDDS causes retinitis pigmentosa 59
Drugs
Diseases
GWAS		FEV1 ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30940813) Ambidextrousness ( 32989287) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Depression ( 29700475) Epilepsy ( 25087078) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Hirschsprung disease ( 27702942) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Problematic alcohol use ( 32451486) Schizophrenia ( 28991256 25056061 19571808 29483656 27922604 30285260) Sleep duration ( 27992416 27494321) Sleep duration (oversleepers vs undersleepers) ( 27494321) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		3 interacting genes: LOX MT-ND1 NPC2	18 interacting genes: AQP6 CCT2 CCT4 CDC42 DTNBP1 GJA5 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 MMGT1 RBX1 TBXA2R TCP1 TMEM14B TMEM205 TMEM88
Entrez ID		79947	7444
HPRD ID		12183	03702
Ensembl ID		ENSG00000117682	ENSG00000028116
Uniprot IDs		Q86SQ9	A8K9L2 Q86Y07
PDB IDs		6W2L 6Z1N	2V62 5UU1 6NCG
Enriched GO Terms of Interacting Partners?
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