TNIP3 and TNIP1

Data Source:
BioGRID (two hybrid)

		TNIP3	TNIP1
Description		TNFAIP3 interacting protein 3	TNFAIP3 interacting protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleoplasm Cytosol
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding	Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Mitogen-activated Protein Kinase Binding
	Biological Process	MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response Protein Deubiquitination Toll-like Receptor 4 Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide	MyD88-dependent Toll-like Receptor Signaling Pathway Translation Defense Response Inflammatory Response Leukocyte Cell-cell Adhesion Glycoprotein Biosynthetic Process Protein Deubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Positive Regulation Of Protein Deubiquitination
Pathways		Ovarian tumor domain proteases	Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Breast cancer ( 23468962) Multiple sclerosis ( 31604244)	Amyotrophic lateral sclerosis ( 29566793) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Cutaneous psoriasis ( 26626624) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 28067908 23128233) Inflammatory skin disease ( 25574825) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Myasthenia gravis ( 23055271) Neutrophil percentage of granulocytes ( 27863252) Psoriasis ( 25854761 25903422 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624 29031612) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 30572963) Rheumatoid arthritis (ACPA-positive) ( 23143596) SjÃ¶gren's syndrome ( 24097067) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26606652 23273568 26502338 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 21750679 31672989 30572963 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		27 interacting genes: CCN3 CYSRT1 DAZAP2 FAM161A KPNA3 KRT40 KRTAP10-3 KRTAP10-8 LITAF LZTS2 MAGEA2 MAGEA2B MTUS2 NBPF19 NOTCH2NLA NTAQ1 PIBF1 PLSCR3 TAX1BP1 TCEANC TNFAIP3 TNIP1 TRIM55 TRIM63 TRIM8 UBC ZBTB8A	95 interacting genes: ABHD17A ADH6 AP1M1 BYSL C8orf33 CCDC112 CCDC121 CCNG1 CDC23 CDC37 CDIP1 CDKN1A CFAP53 CYSRT1 DAZAP2 DPPA4 EFEMP1 EHHADH ELOA FAM161A FAM168A FUS GABARAPL1 GABARAPL2 GIT2 GTF2B GTF2H1 HDAC1 HDDC3 IKBKG KIFC3 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LENG8 LITAF MAGEB18 MAGEH1 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K1 MAPK1 MAPK10 MCM10 MCRS1 MOB1B MOB3C MORF4L1 MORF4L2 NDC80 NFKB1 NIFK NME7 NOD2 OPTN PIBF1 PIN1 PNKP RABAC1 RALBP1 RARA RARG RBFOX1 RNF11 RNF8 RPL5 S100B SELPLG SHTN1 SNIP1 SPATA2 SUMO2 SYT6 TAX1BP1 TCEA2 TCEANC TCEANC2 TNFAIP3 TNIP3 TSG101 TTC39A TTF2 TXLNA TYRO3 UBC VPS33B WTAP ZBTB25 ZMAT2 ZNHIT1
Entrez ID		79931	10318
HPRD ID		16268	09216
Ensembl ID		ENSG00000050730	ENSG00000145901
Uniprot IDs		Q96KP6	A0A0A0MRZ4 A8K4N4 B7Z8K2 Q15025
PDB IDs
Enriched GO Terms of Interacting Partners?
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