TNIP1 and SPATA2

Data Source:
BioGRID (two hybrid)

		TNIP1	SPATA2
Description		TNFAIP3 interacting protein 1	spermatogenesis associated 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Fibrillar Center Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Mitogen-activated Protein Kinase Binding	Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding Ubiquitin-specific Protease Binding
	Biological Process	MyD88-dependent Toll-like Receptor Signaling Pathway Translation Defense Response Inflammatory Response Leukocyte Cell-cell Adhesion Glycoprotein Biosynthetic Process Protein Deubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Positive Regulation Of Protein Deubiquitination	Spermatogenesis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Inflammatory Response Regulation Of Necroptotic Process Necroptotic Process Protein K63-linked Deubiquitination Seminiferous Tubule Development Protein Linear Deubiquitination
Pathways		Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 29566793) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Cutaneous psoriasis ( 26626624) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 28067908 23128233) Inflammatory skin disease ( 25574825) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Myasthenia gravis ( 23055271) Neutrophil percentage of granulocytes ( 27863252) Psoriasis ( 25854761 25903422 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624 29031612) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 30572963) Rheumatoid arthritis (ACPA-positive) ( 23143596) SjÃ¶gren's syndrome ( 24097067) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26606652 23273568 26502338 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 21750679 31672989 30572963 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)	Coronary artery disease ( 29212778) Gut microbiota (beta diversity) ( 27723756) Psoriasis ( 20953189 25574825 18364390)
Interacting Genes		95 interacting genes: ABHD17A ADH6 AP1M1 BYSL C8orf33 CCDC112 CCDC121 CCNG1 CDC23 CDC37 CDIP1 CDKN1A CFAP53 CYSRT1 DAZAP2 DPPA4 EFEMP1 EHHADH ELOA FAM161A FAM168A FUS GABARAPL1 GABARAPL2 GIT2 GTF2B GTF2H1 HDAC1 HDDC3 IKBKG KIFC3 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LENG8 LITAF MAGEB18 MAGEH1 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K1 MAPK1 MAPK10 MCM10 MCRS1 MOB1B MOB3C MORF4L1 MORF4L2 NDC80 NFKB1 NIFK NME7 NOD2 OPTN PIBF1 PIN1 PNKP RABAC1 RALBP1 RARA RARG RBFOX1 RNF11 RNF8 RPL5 S100B SELPLG SHTN1 SNIP1 SPATA2 SUMO2 SYT6 TAX1BP1 TCEA2 TCEANC TCEANC2 TNFAIP3 TNIP3 TSG101 TTC39A TTF2 TXLNA TYRO3 UBC VPS33B WTAP ZBTB25 ZMAT2 ZNHIT1	22 interacting genes: ANKRD11 APP ATP6V1H C2CD6 CCDC102B CEP72 DUT EFHC1 GOLGA2 GPANK1 KAT5 KIFC3 LENG1 MAD1L1 OTULIN PTPN6 RNF31 TBC1D22B TNIP1 TRAF2 TRIM27 ZNF835
Entrez ID		10318	9825
HPRD ID		09216	09636
Ensembl ID		ENSG00000145901	ENSG00000158480
Uniprot IDs		A0A0A0MRZ4 A8K4N4 B7Z8K2 Q15025	A8K0S9 B4DID4 Q9UM82
PDB IDs			5LJM 5LJN
Enriched GO Terms of Interacting Partners?
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