ATAD5 and RAD9A

Data Source:
HPRD (in vitro)

		ATAD5	RAD9A
Description		ATPase family AAA domain containing 5	RAD9 checkpoint clamp component A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Elg1 RFC-like Complex	Nucleus Nucleoplasm Checkpoint Clamp Complex
	Molecular Function	DNA Binding Protein Binding ATP Binding DNA Clamp Unloader Activity	Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Positive Regulation Of DNA Replication DNA Clamp Unloading Positive Regulation Of Cell Cycle G2/M Phase Transition	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Intra-S DNA Damage Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Birth weight ( 31043758) Body mass index ( 28892062) Breast cancer ( 25751625 29059683) Diastolic blood pressure ( 30224653) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 23563607 18391951) Hip circumference adjusted for BMI ( 25673412) Lung cancer in ever smokers ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 28448500)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		2 interacting genes: PCNA RAD9A	38 interacting genes: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CAD CHEK2 CLSPN COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEM1B FEN1 HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 OGG1 PCNA POLB PRKCE RAD17 RAD9B RHNO1 RPA1 RPA2 SF3B3 TDG TLK1 TOPBP1 WRN
Entrez ID		79915	5883
HPRD ID		07792	04788
Ensembl ID		ENSG00000176208	ENSG00000172613
Uniprot IDs		Q96QE3	Q99638
PDB IDs			3A1J 3G65 3GGR 6HM5 6J8Y
Enriched GO Terms of Interacting Partners?
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