RABEP2 and KAT8

Data Source:
BioGRID (affinity chromatography technology)

		RABEP2	KAT8
Description		rabaptin, RAB GTPase binding effector protein 2	lysine acetyltransferase 8
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Centrosome Cytosol Ciliary Basal Body Intracellular Membrane-bounded Organelle	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Nuclear Matrix MLL1 Complex MSL Complex
	Molecular Function	GTPase Activator Activity Protein Binding Growth Factor Activity	Transcription Coregulator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Enzyme Binding Methylated Histone Binding Histone Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Metal Ion Binding Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Endocytosis Signal Transduction Protein Transport Cell Projection Organization Positive Regulation Of GTPase Activity Regulation Of Cilium Assembly	Regulation Of Autophagy Histone Acetylation Myeloid Cell Differentiation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways			HATs acetylate histones
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 31453325) Body mass index variance ( 31453325) Brain morphology (MOSTest) ( 32665545) Cannabis use ( 30150663) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) HDL cholesterol levels ( 32203549) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Obesity ( 23563607)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 25673413) Family history of Alzheimer's disease ( 30617256) Parkinson's disease ( 28892059) Triglyceride levels ( 32154731)
Interacting Genes		7 interacting genes: FBXO25 FRAT1 MAP3K1 RAB4A RAB5A UBC VPS52	12 interacting genes: ATM BAZ2A FOXP3 H4C1 KANSL1 KMT2A MSL3 PAF1 PLAU RNF2 TP53 TP53BP1
Entrez ID		79874	84148
HPRD ID		17948	11381
Ensembl ID		ENSG00000177548	ENSG00000103510
Uniprot IDs		Q9H5N1	Q9H7Z6
PDB IDs			2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC 5H43 5J8C 5J8F 5WCI 6BA2 6BA4 6CT2 6OIN 6OIO 6OIP 6OIQ 6OIR 6OWH 6OWI 6PD8 6PD9 6PDA 6PDB 6PDC 6PDD 6PDE 6PDF 6PDG 7CMR
Enriched GO Terms of Interacting Partners?
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