KDM8 and DCTN5

Data Source:
BioGRID (proximity labelling technology)

		KDM8	DCTN5
Description		lysine demethylase 8	dynactin subunit 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol	Condensed Chromosome Kinetochore Nucleoplasm Centrosome Cytosol Nuclear Membrane
	Molecular Function	Chromatin Binding Endopeptidase Activity Aminopeptidase Activity Protein Binding 2-oxoglutarate-dependent Dioxygenase Activity Methylated Histone Binding Metal Ion Binding Histone Demethylase Activity (H3-K36 Specific) L-arginine 3-hydroxylase Activity	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Proteolysis Protein Destabilization Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Histone H3-K36 Demethylation	Ventricular Septum Development Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Aorta Development Coronary Vasculature Development
Pathways			MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Asthma ( 31959851 31619474) Gut microbiota (bacterial taxa) ( 27723756) Night sleep phenotypes ( 27126917)	Bipolar disorder ( 17554300)
Interacting Genes		6 interacting genes: DDIT4L IFT20 ISY1 MEOX2 NUBPL PCYT2	5 interacting genes: DYNLL1 FATE1 NINL PMEPA1 RBPMS
Entrez ID		79831	84516
HPRD ID		07836	14551
Ensembl ID		ENSG00000155666	ENSG00000166847
Uniprot IDs		A0A0S2Z5P8 A0A0S2Z5T1 Q8N371	Q9BTE1
PDB IDs		3UYJ 4AAP 4GAZ 4GJY 4GJZ 4QU1 5FBJ 6AVS 6AX3 6F4M 6F4N 6F4O 6F4P 6F4Q 6F4R 6F4S 6F4T 6I9L 6I9M 6I9N	5NW4
Enriched GO Terms of Interacting Partners?
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