ST7 and MYOT

Data Source:
BioGRID (two hybrid)

		ST7	MYOT
Description		suppression of tumorigenicity 7	myotilin
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Plasma Membrane Actin Cytoskeleton Z Disc Axon Sarcolemma Neuronal Cell Body
	Molecular Function		Actin Binding Protein Binding Axon Guidance Receptor Activity Structural Constituent Of Muscle Alpha-actinin Binding
	Biological Process	Extracellular Matrix Organization Regulation Of Cell Differentiation	Muscle Contraction Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Synapse Organization
Pathways
Drugs
Diseases			Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Limb-girdle muscular dystrophy (LGMD)
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Intraocular pressure ( 30591961) Response to alcohol consumption (flushing response) ( 29460428) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Atrial fibrillation ( 30061737) Heart rate ( 23583979) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)
Interacting Genes		8 interacting genes: ACTN2 DCAF4 MYOT NFKBIA RACK1 SNAPIN UBE2D3 ZFYVE9	17 interacting genes: ACTN1 ACTN2 ACTN3 APP AXIN1 DOCK9 FLNA FLNC GPRASP2 LRP12 NME7 PDLIM3 PFDN5 ST7 TFG TRIM55 TRIM63
Entrez ID		7982	9499
HPRD ID		09015	04981
Ensembl ID		ENSG00000004866	ENSG00000120729
Uniprot IDs		Q9NRC1 X5DRA0	A0A0C4DFM5 B4DT68 Q9UBF9
PDB IDs			2KDG 2KKQ
Enriched GO Terms of Interacting Partners?
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