VTCN1 and TRIM33

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		VTCN1	TRIM33
Description		V-set domain containing T cell activation inhibitor 1	tripartite motif containing 33
Image
GO Annotations	Cellular Component	External Side Of Plasma Membrane Integral Component Of Membrane	Nucleus Nucleoplasm
	Molecular Function	Molecular_function Signaling Receptor Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Co-SMAD Binding R-SMAD Binding
	Biological Process	Regulation Of Cytokine Production Adaptive Immune Response Negative Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation	Negative Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Transcription, DNA-templated
Pathways			Downregulation of SMAD2/3:SMAD4 transcriptional activity
Drugs
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 19116933)	Autism ( 24189344) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		1 interacting genes: BTLA	10 interacting genes: CTNNB1 ERG H3C1 NLGN3 SMAD3 TRIM24 UBE2D2 UBE2D3 UBE2E1 UBE2N
Entrez ID		79679	51592
HPRD ID		06429	10423
Ensembl ID		ENSG00000134258	ENSG00000197323
Uniprot IDs		Q7Z7D3	B3KN30 Q9UPN9
PDB IDs		4GOS	3U5M 3U5N 3U5O 3U5P 5MR8
Enriched GO Terms of Interacting Partners?
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