TRIM33 and NLGN3

Data Source:
BioGRID (two hybrid)

		TRIM33	NLGN3
Description		tripartite motif containing 33	neuroligin 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle Synapse Excitatory Synapse Spanning Component Of Membrane Presynapse Symmetric, GABA-ergic, Inhibitory Synapse Asymmetric, Glutamatergic, Excitatory Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Co-SMAD Binding R-SMAD Binding	Protein Binding Signaling Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Transcription, DNA-templated	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Receptor-mediated Endocytosis Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Learning Adult Behavior Social Behavior Synaptic Vesicle Endocytosis Axon Extension Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Inhibitory Postsynaptic Potential Vocalization Behavior Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynapse Assembly Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of AMPA Receptor Activity
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Autism ( 24189344) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Prostate cancer ( 25217961)
Interacting Genes		10 interacting genes: CTNNB1 ERG H3C1 NLGN3 SMAD3 TRIM24 UBE2D2 UBE2D3 UBE2E1 UBE2N	55 interacting genes: ALPP AP2A2 ATF4 C1orf122 C1QA CCAR2 CGB3 CTSD DLG2 DLG3 DLG4 DPEP2 EBPL EFS FANCG FBLN1 FHOD1 FKBP1A FLNA GDF15 GUK1 HID1 ITPRIP LGALS1 MAN2C1 MAP1S MEOX2 MIEN1 NFATC4 NRDC NRXN1 NRXN2 NRXN3 OAZ1 OR1F12 PKIB PLB1 PLCB4 PRDX2 PSAP PSG1 PSG11 PSG3 PSG4 PSG5 QARS1 SPAG5 SPINT1 SSR4 TNNT3 TRIM33 TXNIP UBQLN1 UBXN6 UQCRC1
Entrez ID		51592	54413
HPRD ID		10423	02275
Ensembl ID		ENSG00000197323	ENSG00000196338
Uniprot IDs		B3KN30 Q9UPN9	B7Z3P8 Q4G160 Q6MZK0 Q9NZ94 X5D2P6 X5D7L6 X5DNV3
PDB IDs		3U5M 3U5N 3U5O 3U5P 5MR8
Enriched GO Terms of Interacting Partners?
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