NEIL1 and MAP3K11

Data Source:
BioGRID (affinity chromatography technology)

		NEIL1	MAP3K11
Description		nei like DNA glycosylase 1	mitogen-activated protein kinase kinase kinase 11
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center	Cytoplasm Centrosome Microtubule Membrane
	Molecular Function	Damaged DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein C-terminus Binding Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Base-excision Repair Response To Oxidative Stress Negative Regulation Of Nuclease Activity Depyrimidination	Activation Of MAPK Activity Protein Phosphorylation Microtubule-based Process JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective Base Excision Repair Associated with NEIL1	RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs		Iron Copper Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate	Fostamatinib
Diseases
GWAS			Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil counts ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969)
Interacting Genes		6 interacting genes: APP HUS1 LIG3 POLB RAD1 XRCC1	27 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 EPS8 IKBKB KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 PIN1 RAC1 RHOG SH3RF1 STUB1 TRAF6
Entrez ID		79661	4296
HPRD ID		12314	02502
Ensembl ID		ENSG00000140398	ENSG00000173327
Uniprot IDs		Q96FI4	A0A024R5E6 Q16584
PDB IDs		1TDH 4NRV 5ITQ 5ITR 5ITT 5ITU 5ITX 5ITY	5K26 5K28 6AQB 6CQ7
Enriched GO Terms of Interacting Partners?
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