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MAP3K11
Description
mitogen-activated protein kinase kinase kinase 11
Image
GO Annotations
Cellular Component
Cytoplasm
Centrosome
Microtubule
Membrane
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
JUN Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Mitogen-activated Protein Kinase Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Biological Process
Activation Of MAPK Activity
Protein Phosphorylation
Microtubule-based Process
JNK Cascade
Activation Of JNKK Activity
Activation Of JUN Kinase Activity
Cell Death
Positive Regulation Of Apoptotic Process
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Neuron Apoptotic Process
Cell Cycle G1/S Phase Transition
Positive Regulation Of JNK Cascade
Protein Autophosphorylation
Pathways
RAF activation
Signaling by moderate kinase activity BRAF mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Drugs
Fostamatinib
Diseases
GWAS
Acne (severe) (
24927181
30542056
)
Coronary artery disease (
29212778
)
Eosinophil counts (
27863252
)
Estimated glomerular filtration rate (
31015462
)
Gout (
25646370
)
Mean platelet volume (
27863252
)
Refractive error (
32231278
)
Serum uric acid levels (
32514006
)
Sum eosinophil basophil counts (
27863252
)
Type 2 diabetes (
28566273
30297969
)
Novel Interacting Genes
6 novel interacting genes:
FKBP2
MYO7A
NEIL1
PNLIPRP2
TIA1
TSGA10IP
Interacting Genes
27 interacting genes:
AKT1
APP
CDC42
CHUK
CLEC4G
COPS5
EPS8
IKBKB
KIF17
KIF3A
KIF3B
KIFAP3
MAP2K4
MAP2K7
MAP3K12
MAP3K21
MAP4K1
MAP4K2
MAPK8IP1
MAPK8IP2
MAPK8IP3
PIN1
RAC1
RHOG
SH3RF1
STUB1
TRAF6
Entrez ID
4296
HPRD ID
02502
Ensembl ID
ENSG00000173327
Uniprot IDs
A0A024R5E6
Q16584
PDB IDs
5K26
5K28
6AQB
6CQ7
Enriched GO Terms of Interacting Partners
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