CRELD2 and CHRNB2

Data Source:
HPRD (two hybrid)

		CRELD2	CHRNB2
Description		cysteine rich with EGF like domains 2	cholinergic receptor nicotinic beta 2 subunit
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Golgi Apparatus	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Integral Component Of Membrane Neuron Projection Plasma Membrane Raft Synapse Postsynaptic Membrane
	Molecular Function	Protein Disulfide Isomerase Activity Calcium Ion Binding Protein Binding	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding
	Biological Process	Protein Phosphopantetheinylation	Response To Hypoxia Ion Transport Calcium Ion Transport Smooth Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Visual Perception Sensory Perception Of Sound Learning Memory Locomotory Behavior Associative Learning Visual Learning Regulation Of Dopamine Secretion Sensory Perception Of Pain Vestibulocochlear Nerve Development Optic Nerve Morphogenesis Lateral Geniculate Nucleus Development Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of B Cell Proliferation Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Dopamine Secretion Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Social Behavior Regulation Of Dopamine Metabolic Process B Cell Activation Response To Cocaine Regulation Of Circadian Sleep/wake Cycle, REM Sleep Regulation Of Membrane Potential Response To Ethanol Negative Regulation Of Action Potential Regulation Of Dendrite Morphogenesis Nervous System Process Cognition Membrane Depolarization Regulation Of Synapse Assembly Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition Acetylcholine Receptor Signaling Pathway Response To Acetylcholine
Pathways			Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs			Nicotine Butabarbital Methadone Dextromethorphan Atropine Mecamylamine Scopolamine Isoflurane Ethanol Physostigmine Decamethonium Varenicline Pozanicline RPI-78M Rivanicline Epibatidine Cytisine
Diseases			Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		Acne (severe) ( 24927181)	Nicotine dependence ( 28440896) Smoking behaviour (cigarettes smoked per day) ( 30679032)
Interacting Genes		7 interacting genes: C8orf33 CDKN2A CHRNA4 CHRNB2 LTB4R2 MEST SUV39H1	3 interacting genes: CHRNA2 CHRNA4 CRELD2
Entrez ID		79174	1141
HPRD ID		08455	00335
Ensembl ID		ENSG00000184164	ENSG00000160716
Uniprot IDs		Q6UXH1	P17787 Q5SXY3
PDB IDs			2GVT 2K58 2K59 2KSR 2LM2 5KXI 6CNJ 6CNK 6UR8 6USF
Enriched GO Terms of Interacting Partners?
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