CHRNB2 and CRELD2

Data Source:
HPRD (two hybrid)

		CHRNB2	CRELD2
Description		cholinergic receptor nicotinic beta 2 subunit	cysteine rich with EGF like domains 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Integral Component Of Membrane Neuron Projection Plasma Membrane Raft Synapse Postsynaptic Membrane	Extracellular Space Endoplasmic Reticulum Golgi Apparatus
	Molecular Function	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding	Protein Disulfide Isomerase Activity Calcium Ion Binding Protein Binding
	Biological Process	Response To Hypoxia Ion Transport Calcium Ion Transport Smooth Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Visual Perception Sensory Perception Of Sound Learning Memory Locomotory Behavior Associative Learning Visual Learning Regulation Of Dopamine Secretion Sensory Perception Of Pain Vestibulocochlear Nerve Development Optic Nerve Morphogenesis Lateral Geniculate Nucleus Development Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of B Cell Proliferation Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Dopamine Secretion Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Social Behavior Regulation Of Dopamine Metabolic Process B Cell Activation Response To Cocaine Regulation Of Circadian Sleep/wake Cycle, REM Sleep Regulation Of Membrane Potential Response To Ethanol Negative Regulation Of Action Potential Regulation Of Dendrite Morphogenesis Nervous System Process Cognition Membrane Depolarization Regulation Of Synapse Assembly Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition Acetylcholine Receptor Signaling Pathway Response To Acetylcholine	Protein Phosphopantetheinylation
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Nicotine Butabarbital Methadone Dextromethorphan Atropine Mecamylamine Scopolamine Isoflurane Ethanol Physostigmine Decamethonium Varenicline Pozanicline RPI-78M Rivanicline Epibatidine Cytisine
Diseases		Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		Nicotine dependence ( 28440896) Smoking behaviour (cigarettes smoked per day) ( 30679032)	Acne (severe) ( 24927181)
Interacting Genes		3 interacting genes: CHRNA2 CHRNA4 CRELD2	7 interacting genes: C8orf33 CDKN2A CHRNA4 CHRNB2 LTB4R2 MEST SUV39H1
Entrez ID		1141	79174
HPRD ID		00335	08455
Ensembl ID		ENSG00000160716	ENSG00000184164
Uniprot IDs		P17787 Q5SXY3	Q6UXH1
PDB IDs		2GVT 2K58 2K59 2KSR 2LM2 5KXI 6CNJ 6CNK 6UR8 6USF
Enriched GO Terms of Interacting Partners?
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