ERI3 and CENPO

Data Source:
BioGRID (two hybrid)

		ERI3	CENPO
Description		ERI1 exoribonuclease family member 3	centromere protein O
Image			No pdb structure
GO Annotations	Cellular Component		Condensed Nuclear Chromosome Kinetochore Nucleoplasm Cytosol Nuclear Body Mis6-Sim4 Complex
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Metal Ion Binding	Protein Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) DNA Catabolic Process, Exonucleolytic	CENP-A Containing Nucleosome Assembly
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Body mass index ( 26426971 29273807) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cognitive function ( 28093568) Coronary artery disease ( 29212778) Height ( 28552196 25282103 23563607) Multiple sclerosis ( 24076602) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Trunk fat mass ( 28552196) Type 1 diabetes ( 21980299)
Interacting Genes		3 interacting genes: CENPO CPEB2 PRNP	7 interacting genes: CENPP CEP170P1 DCDC2 ERI3 FOS FOSB NECAB2
Entrez ID		79033	79172
HPRD ID		15175	14414
Ensembl ID		ENSG00000117419	ENSG00000138092
Uniprot IDs		B4DEX5 B4DN03 O43414	Q9BU64
PDB IDs		2XRI
Enriched GO Terms of Interacting Partners?
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