RAB7A and FABP6

Data Source:
BioGRID (affinity chromatography technology)

		RAB7A	FABP6
Description		RAB7A, member RAS oncogene family	fatty acid binding protein 6
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GO Annotations	Cellular Component	Autophagosome Membrane Lysosome Lysosomal Membrane Late Endosome Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Retromer Complex Late Endosome Membrane Extrinsic Component Of Lysosome Membrane Melanosome Membrane Phagocytic Vesicle Extracellular Exosome	Cytoplasm Cytosol Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Retromer Complex Binding	Lipid Binding
	Biological Process	Autophagosome Assembly Protein Targeting To Lysosome Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Lipid Catabolic Process Viral Release From Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein To Membrane Docking Retrograde Transport, Endosome To Golgi Neutrophil Degranulation Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Endosome To Plasma Membrane Protein Transport Multi-organism Intercellular Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation	Lipid Metabolic Process Lipid Transport Negative Regulation Of Cell Population Proliferation Triglyceride Catabolic Process
Pathways		MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Suppression of autophagy	Recycling of bile acids and salts Triglyceride catabolism NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs		Guanosine-5'-Diphosphate	Cholic Acid Glycocholic acid Taurocholic acid
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)	Cardiometabolic and hematological traits ( 27668658) Heel bone mineral density ( 30598549) Mean platelet volume ( 32888494) Platelet count ( 29403010 32888494) Platelet distribution width ( 32888494)
Interacting Genes		27 interacting genes: CHM KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 SLC2A4 SNX3 TP53 UCHL5 VPS11 VPS16 VPS18 VPS26A VPS29 VPS39 VPS41
Entrez ID		7879	2172
HPRD ID		03805	02689
Ensembl ID		ENSG00000075785	ENSG00000170231
Uniprot IDs		A0A158RFU6 P51149	P51161
PDB IDs		1T91 1YHN 3LAW 6IYB 6WCW	1O1U 1O1V 2MM3 5L8I 5L8N 5L8O
Enriched GO Terms of Interacting Partners?
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