PAX8 and WBP2

Data Source:
HPRD (in vivo, in vitro)

		PAX8	WBP2
Description		paired box 8	WW domain binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Cytoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Protein Binding Estrogen Receptor Binding Chromatin DNA Binding
	Biological Process	Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Anatomical Structure Morphogenesis Thyroid Gland Development Thyroid-stimulating Hormone Signaling Pathway Pronephric Field Specification Inner Ear Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Pronephros Development Anatomical Structure Development Cellular Response To Gonadotropin Stimulus Otic Vesicle Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Metanephric Nephron Tubule Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid-stimulating Hormone Secretion	Response To Progesterone Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Estrogen Establishment Of Protein Localization Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Progesterone Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Positive Regulation Of Histone H3-K14 Acetylation
Pathways
Drugs
Diseases		Thyroid cancer Congenital nongoitrous hypothyroidism (CHNG)
GWAS		Blood urea nitrogen levels ( 31152163) Body mass index ( 28552196) Creatinine levels ( 29403010) Depressive symptom (sleep problems) (binary trait) ( 31530331) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 29403010) Lymphocyte counts ( 27863252) Mucinous ovarian carcinoma ( 26075790) Optic disc size ( 31809533) Renal function-related traits (BUN) ( 22797727) Sleep duration ( 27992416 27494321 25469926) Sleep duration (long sleep) ( 30846698) Sleep duration (oversleepers vs undersleepers) ( 27494321) Sleep duration (short sleep) ( 30846698) Sleep traits (multi-trait analysis) ( 27992416) Urate levels ( 31578528) Weight ( 28552196)	Adult body size ( 32376654) Platelet count ( 32888494) Red blood cell count ( 32888494) White matter hyperintensities ( 32358547)
Interacting Genes		22 interacting genes: ANXA7 AURKA CDK3 CHUK CXCL9 DOK4 EP300 GCM2 HOXC8 HOXC9 ID2 LONRF1 NKX2-1 PKM POU2AF1 SAE1 SERINC1 SKP2 SMAD3 SS18L1 TLE5 WBP2	54 interacting genes: ANAPC1 ANKRD13A ANKRD13D ARCN1 BAG3 CCT7 CLEC4G COPA COPB1 COPB2 COPE COPG1 CUEDC1 DDX17 EEF1B2 EPN2 ESR1 GRPEL1 H4C1 HOMER3 HUWE1 ITCH KRT18 KRT8 KRT9 LGALS8 MAGEA4 MAGI1 MYO6 NEDD4 NEDD4L PAX8 POLH RHBDD3 RNF168 RPS27A RPS3 SDHA SEPTIN3 SMAD5 TDP2 TOLLIP TOM1L2 UBA52 UBC UBE2D3 UBE2E3 UBE3A UBQLN1 UIMC1 WWP1 WWP2 WWTR1 YAP1
Entrez ID		7849	23558
HPRD ID		01335	06097
Ensembl ID		ENSG00000125618	ENSG00000132471
Uniprot IDs		A0A024R4X8 A0A024R524 Q06710 R9W7C9	A0A024R8L1 Q969T9
PDB IDs		2K27
Enriched GO Terms of Interacting Partners?
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