XPC and MRPS25

Data Source:
BioGRID (affinity chromatography technology)

		XPC	MRPS25
Description		XPC complex subunit, DNA damage recognition and repair factor	mitochondrial ribosomal protein S25
Image
GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 2 Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle XPC Complex Site Of DNA Damage	Mitochondrion Mitochondrial Inner Membrane Ribosome
	Molecular Function	Heteroduplex DNA Loop Binding Bubble DNA Binding Damaged DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Protein Binding Protein-containing Complex Binding	Structural Constituent Of Ribosome
	Biological Process	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Assembly Mismatch Repair Response To UV-B Response To Auditory Stimulus Intra-S DNA Damage Checkpoint Response To Drug Positive Regulation Of Transcription, DNA-templated Global Genome Nucleotide-excision Repair UV-damage Excision Repair Regulation Of Mitotic Cell Cycle Phase Transition UV-damage Excision Repair, DNA Incision	Mitochondrial Translational Elongation Mitochondrial Translational Termination
Pathways		SUMOylation of DNA damage response and repair proteins DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Interacting Genes		15 interacting genes: CETN2 DDB2 ERCC3 GTF2H1 LSM3 MDM2 PSMD4 RAD23A RAD23B RPA1 SMAD1 TDG USP7 XPA ZNF512B	1 interacting genes: ERCC6
Entrez ID		7508	64432
HPRD ID		02046	17594
Ensembl ID		ENSG00000154767	ENSG00000131368
Uniprot IDs		Q01831 X5DRB1	P82663
PDB IDs		2A4J 2GGM 2OBH 2RVB	3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG
Enriched GO Terms of Interacting Partners?
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