UGT2B7 and CYP3A4

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		UGT2B7	CYP3A4
Description		UDP glucuronosyltransferase family 2 member B7	cytochrome P450 family 3 subfamily A member 4
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Retinoic Acid Binding UDP-glycosyltransferase Activity Glucuronosyltransferase Activity	Monooxygenase Activity Steroid Binding Iron Ion Binding Protein Binding Steroid Hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxygen Binding Enzyme Binding Heme Binding Vitamin D3 25-hydroxylase Activity Caffeine Oxidase Activity Quinine 3-monooxygenase Activity Testosterone 6-beta-hydroxylase Activity Aromatase Activity Vitamin D 24-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity 1,8-cineole 2-exo-monooxygenase Activity
	Biological Process	Lipid Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Cellular Glucuronidation	Lipid Hydroxylation Lipid Metabolic Process Steroid Catabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Heterocycle Metabolic Process Oxidative Demethylation
Pathways		Glucuronidation	Xenobiotics Aflatoxin activation and detoxification Biosynthesis of maresin-like SPMs
Drugs			Glutathione Isoniazid Pradefovir mesylate Casopitant Diacerein
Diseases
GWAS		AR-C124910XX levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Obesity-related traits ( 23251661) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Urinary metabolite levels in chronic kidney disease ( 31959995)	Metabolic traits ( 21886157) Neonatal cytokine/chemokine levels (maternal genetic effect) ( 30134952) Pre-treatment viral load in HIV-1 infection ( 31219150) Sex hormone levels ( 26014426) Tacrolimus trough concentration in kidney transplant patients ( 29160300) Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875)
Interacting Genes		2 interacting genes: CYP3A4 GABRA3	8 interacting genes: CYB5A CYP2C9 GK POR PRKACA PRKCA STUB1 UGT2B7
Entrez ID		7364	1576
HPRD ID		02508	00484
Ensembl ID		ENSG00000171234	ENSG00000160868
Uniprot IDs		E9PBP8 P16662	P08684 Q6GRK0
PDB IDs		2O6L	1TQN 1W0E 1W0F 1W0G 2J0D 2V0M 3NXU 3TJS 3UA1 4D6Z 4D75 4D78 4D7D 4I3Q 4I4G 4I4H 4K9T 4K9U 4K9V 4K9W 4K9X 4NY4 5A1P 5A1R 5G5J 5TE8 5VC0 5VCC 5VCD 5VCE 5VCG 6BCZ 6BD5 6BD6 6BD7 6BD8 6BDH 6BDI 6BDK 6BDM 6OO9 6OOA 6OOB
Enriched GO Terms of Interacting Partners?
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