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CYP3A4
Description
cytochrome P450 family 3 subfamily A member 4
Image
GO Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Intracellular Membrane-bounded Organelle
Molecular Function
Monooxygenase Activity
Steroid Binding
Iron Ion Binding
Protein Binding
Steroid Hydroxylase Activity
Retinoic Acid 4-hydroxylase Activity
Oxidoreductase Activity
Oxygen Binding
Enzyme Binding
Heme Binding
Vitamin D3 25-hydroxylase Activity
Caffeine Oxidase Activity
Quinine 3-monooxygenase Activity
Testosterone 6-beta-hydroxylase Activity
Aromatase Activity
Vitamin D 24-hydroxylase Activity
Estrogen 16-alpha-hydroxylase Activity
Estrogen 2-hydroxylase Activity
1,8-cineole 2-exo-monooxygenase Activity
Biological Process
Lipid Hydroxylation
Lipid Metabolic Process
Steroid Catabolic Process
Xenobiotic Metabolic Process
Steroid Metabolic Process
Cholesterol Metabolic Process
Androgen Metabolic Process
Estrogen Metabolic Process
Alkaloid Catabolic Process
Monoterpenoid Metabolic Process
Drug Metabolic Process
Calcitriol Biosynthetic Process From Calciol
Vitamin D Metabolic Process
Retinol Metabolic Process
Retinoic Acid Metabolic Process
Drug Catabolic Process
Exogenous Drug Catabolic Process
Long-chain Fatty Acid Biosynthetic Process
Heterocycle Metabolic Process
Oxidative Demethylation
Pathways
Xenobiotics
Aflatoxin activation and detoxification
Biosynthesis of maresin-like SPMs
Drugs
Glutathione
Isoniazid
Pradefovir mesylate
Casopitant
Diacerein
Diseases
GWAS
Metabolic traits (
21886157
)
Neonatal cytokine/chemokine levels (maternal genetic effect) (
30134952
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Sex hormone levels (
26014426
)
Tacrolimus trough concentration in kidney transplant patients (
29160300
)
Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor (
25935875
)
Interacting Genes
8 interacting genes:
CYB5A
CYP2C9
GK
POR
PRKACA
PRKCA
STUB1
UGT2B7
Entrez ID
1576
HPRD ID
00484
Ensembl ID
ENSG00000160868
Uniprot IDs
P08684
Q6GRK0
PDB IDs
1TQN
1W0E
1W0F
1W0G
2J0D
2V0M
3NXU
3TJS
3UA1
4D6Z
4D75
4D78
4D7D
4I3Q
4I4G
4I4H
4K9T
4K9U
4K9V
4K9W
4K9X
4NY4
5A1P
5A1R
5G5J
5TE8
5VC0
5VCC
5VCD
5VCE
5VCG
6BCZ
6BD5
6BD6
6BD7
6BD8
6BDH
6BDI
6BDK
6BDM
6OO9
6OOA
6OOB
Enriched GO Terms of Interacting Partners
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