TYRP1 and TYR

Data Source:
HPRD (in vivo)

		TYRP1	TYR
Description		tyrosinase related protein 1	tyrosinase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Melanosome Membrane Melanosome Intracellular Vesicle	Nucleus Cytoplasm Lysosome Golgi-associated Vesicle Cytosol Integral Component Of Membrane Melanosome Membrane Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Monophenol Monooxygenase Activity Protein Binding Oxidoreductase Activity Protein Homodimerization Activity Metal Ion Binding	Monophenol Monooxygenase Activity Copper Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Melanocyte Differentiation Melanosome Organization Melanin Biosynthetic Process Acetoacetic Acid Metabolic Process Positive Regulation Of Melanin Biosynthetic Process	Melanin Biosynthetic Process From Tyrosine Eye Pigment Biosynthetic Process Visual Perception Cell Population Proliferation Response To UV Response To Blue Light Response To Vitamin D Melanin Biosynthetic Process Pigmentation Thymus Development Response To CAMP
Pathways		Melanin biosynthesis	Melanin biosynthesis
Drugs			NADH Azelaic acid Monobenzone Mimosine Hydroquinone Arbutin Hexylresorcinol
Diseases		Oculocutaneous albinism (OCA)	Oculocutaneous albinism (OCA)
GWAS		Adult body size ( 32376654) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Blue vs. green eyes ( 18488028) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Eye color ( 23548203 30664655) Eye color (brightness) ( 30664655) Eye color (saturation) ( 30664655) Eye color traits ( 30166351) Hair color ( 22556244 29662168) Low tan response ( 29739929) Metabolite levels ( 23823483) Mild to moderate chronic kidney disease ( 31178898) Mitochondrial DNA copy number ( 30704525) Neuroticism ( 27089181) Nevus count or cutaneous melanoma ( 32341527) Psoriasis ( 30921485) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Skin pigmentation ( 29195075) Smoking status (ever vs never smokers) ( 30643258)	Age-related macular degeneration ( 23326517) Basal cell carcinoma ( 31174203 27539887) Blond vs. brown/black hair color ( 30531825) Blue vs. green eyes ( 17952075) Brown vs. black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Cutaneous squamous cell carcinoma ( 27424798 32041948) Eye color ( 20585627) Eye color (brightness) ( 30664655) Fish- and plant-related diet ( 32066663) Freckles ( 17952075) Hair color ( 30664655 29662168 26926045) Intraocular pressure ( 29617998) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Macular thickness ( 30535121) Melanoma ( 21983787 28212542 24980573 19578364) Neurociticism ( 29500382) Nevus count or cutaneous melanoma ( 32341527 30429480) Non-melanoma skin cancer ( 29739929) Optic disc size ( 31809533) Skin pigmentation ( 31315583 30664655 17999355) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 17952075) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 20410501 27723757 22561518)
Interacting Genes		3 interacting genes: GIPC1 SEC22A TYR	1 interacting genes: TYRP1
Entrez ID		7306	7299
HPRD ID		00283	06086
Ensembl ID		ENSG00000107165	ENSG00000077498
Uniprot IDs		P17643	L8B082 P14679
PDB IDs		5M8L 5M8M 5M8N 5M8O 5M8P 5M8Q 5M8R 5M8S 5M8T
Enriched GO Terms of Interacting Partners?
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