TYR

Description		tyrosinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Golgi-associated Vesicle Cytosol Integral Component Of Membrane Melanosome Membrane Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Monophenol Monooxygenase Activity Copper Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Melanin Biosynthetic Process From Tyrosine Eye Pigment Biosynthetic Process Visual Perception Cell Population Proliferation Response To UV Response To Blue Light Response To Vitamin D Melanin Biosynthetic Process Pigmentation Thymus Development Response To CAMP
Pathways		Melanin biosynthesis
Drugs		NADH Azelaic acid Monobenzone Mimosine Hydroquinone Arbutin Hexylresorcinol
Diseases		Oculocutaneous albinism (OCA)
GWAS		Age-related macular degeneration ( 23326517) Basal cell carcinoma ( 31174203 27539887) Blond vs. brown/black hair color ( 30531825) Blue vs. green eyes ( 17952075) Brown vs. black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Cutaneous squamous cell carcinoma ( 27424798 32041948) Eye color ( 20585627) Eye color (brightness) ( 30664655) Fish- and plant-related diet ( 32066663) Freckles ( 17952075) Hair color ( 30664655 29662168 26926045) Intraocular pressure ( 29617998) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Macular thickness ( 30535121) Melanoma ( 21983787 28212542 24980573 19578364) Neurociticism ( 29500382) Nevus count or cutaneous melanoma ( 32341527 30429480) Non-melanoma skin cancer ( 29739929) Optic disc size ( 31809533) Skin pigmentation ( 31315583 30664655 17999355) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 17952075) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 20410501 27723757 22561518)
Novel Interacting Genes		2 novel interacting genes: PRICKLE1 UBASH3A
Interacting Genes		1 interacting genes: TYRP1
Entrez ID		7299
HPRD ID		06086
Ensembl ID		ENSG00000077498
Uniprot IDs		L8B082 P14679
PDB IDs
Enriched GO Terms of Interacting Partners?
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