FAM166B and TFAP2D

Data Source:
BioGRID (two hybrid)

		FAM166B	TFAP2D
Description		family with sequence similarity 166 member B	transcription factor AP-2 delta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Transcription Regulator Complex
	Molecular Function		RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding
	Biological Process		Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development Inferior Colliculus Development
Pathways			Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
Drugs
Diseases
GWAS			anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 29273807) Breast size ( 22747683) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Fruit consumption ( 32066663) Hand grip strength ( 29691431) Overweight status ( 25133637) Parahippocampal gyrus volume ( 31530798) Refractive error ( 32231278) Response to citalopram or escitalopram in depression ( 27622933) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcutaneous adipose tissue ( 29178545) Systolic blood pressure ( 28135244) Western dietary pattern ( 28644415)
Interacting Genes		22 interacting genes: ABI2 ATPAF2 CCDC24 CLIC3 GPANK1 GPHB5 KRTAP6-2 LCK LENG8 MAGEB4 MGAT5B MORN3 MYOZ3 PIK3R3 POU2AF1 QRICH1 RBPMS RFC5 TENT5B TFAP2D TLX3 TOLLIP	64 interacting genes: ADAM12 ADAMTSL4 AGR2 AKAP8L BAG4 CAMK2A CARD10 CDPF1 CEP76 CNFN CSNK2B CYSRT1 FAM166B FAM168A GUCD1 GYS1 HOXD12 IKZF3 INCA1 KLHL20 KPRP KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-3 KRTAP15-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP9-2 KRTAP9-3 MLH1 OIP5 PITX1 PLEKHG4 PRR22 PSMB4 RAD54L2 SIVA1 SLAIN1 SPRY1 SSC4D TEPSIN TEX37 TLE5 TNS2 TRAF1 TRIM42 TSC1 USP54 VPS37C ZBTB32 ZMYND12
Entrez ID		730112	83741
HPRD ID			11627
Ensembl ID		ENSG00000215187	ENSG00000008197
Uniprot IDs		A8MTA8 B7ZW26 B7ZW33	Q7Z6R9
PDB IDs
Enriched GO Terms of Interacting Partners?
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