TYR and PRICKLE1

Data Source:
BioGRID (affinity chromatography technology)

		TYR	PRICKLE1
Description		tyrosinase	prickle planar cell polarity protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Golgi-associated Vesicle Cytosol Integral Component Of Membrane Melanosome Membrane Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Nucleus Cytosol Nuclear Membrane
	Molecular Function	Monophenol Monooxygenase Activity Copper Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding Zinc Ion Binding
	Biological Process	Melanin Biosynthetic Process From Tyrosine Eye Pigment Biosynthetic Process Visual Perception Cell Population Proliferation Response To UV Response To Blue Light Response To Vitamin D Melanin Biosynthetic Process Pigmentation Thymus Development Response To CAMP	Neural Tube Closure Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aorta Development Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Coronary Vasculature Development Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation
Pathways		Melanin biosynthesis	Asymmetric localization of PCP proteins
Drugs		NADH Azelaic acid Monobenzone Mimosine Hydroquinone Arbutin Hexylresorcinol
Diseases		Oculocutaneous albinism (OCA)	Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Age-related macular degeneration ( 23326517) Basal cell carcinoma ( 31174203 27539887) Blond vs. brown/black hair color ( 30531825) Blue vs. green eyes ( 17952075) Brown vs. black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Cutaneous squamous cell carcinoma ( 27424798 32041948) Eye color ( 20585627) Eye color (brightness) ( 30664655) Fish- and plant-related diet ( 32066663) Freckles ( 17952075) Hair color ( 30664655 29662168 26926045) Intraocular pressure ( 29617998) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Macular thickness ( 30535121) Melanoma ( 21983787 28212542 24980573 19578364) Neurociticism ( 29500382) Nevus count or cutaneous melanoma ( 32341527 30429480) Non-melanoma skin cancer ( 29739929) Optic disc size ( 31809533) Skin pigmentation ( 31315583 30664655 17999355) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 17952075) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 20410501 27723757 22561518)	Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582 31826910) Endometrial cancer (Non-endometrioid histology) ( 30093612) Graves' disease ( 22922229) Heart failure ( 20445134) Hip circumference adjusted for BMI ( 28552196) Impulsivity (non-planning) ( 30718321) Inferior parietal cortex volume ( 31530798) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Parkinson's disease ( 27182965) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		1 interacting genes: TYRP1	7 interacting genes: BYSL JRK KIF9 PRPF31 SMURF2 UTP14C VIP
Entrez ID		7299	144165
HPRD ID		06086	16341
Ensembl ID		ENSG00000077498	ENSG00000139174
Uniprot IDs		L8B082 P14679	A0A024R0W7 B3KVG3 B3KVG6 Q96MT3
PDB IDs
Enriched GO Terms of Interacting Partners?
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