TXK and UTP18

Data Source:
BioGRID (proximity labelling technology)

		TXK	UTP18
Description		TXK tyrosine kinase	UTP18 small subunit processome component
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Nucleus Nucleoplasm Nucleolus Nuclear Membrane Small-subunit Processome Pwp2p-containing Subcomplex Of 90S Preribosome
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding	RNA Binding
	Biological Process	Cytokine Production Adaptive Immune Response Protein Phosphorylation Activation Of Phospholipase C Activity Integrin-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Platelet Activation Positive Regulation Of Interferon-gamma Production Peptidyl-tyrosine Autophosphorylation Tissue Regeneration Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Interferon-gamma-mediated Signaling Pathway	RRNA Processing
Pathways		FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS		Crohn's disease ( 23128233) Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) Platelet distribution width ( 32888494 27863252)	Bipolar disorder ( 31043756) Menarche (age at onset) ( 27182965) Metabolite levels ( 23823483)
Interacting Genes		38 interacting genes: CBY2 CCDC33 CCR5 CLNK CRK CTLA4 DOK2 DUSP6 EFHC2 EGFR ERBB2 ERBB3 ERBB4 FYN GRB10 GRB2 HOMEZ IKZF1 IKZF4 JRK KIT LCP2 MET NCK2 NELFCD PIK3R1 PRDM14 RBAK SH2D2A SOCS3 SOCS6 SRC STAP2 TNS4 YTHDC1 ZNF587 ZNF792 ZNF835	2 interacting genes: CSNK2A1 ERBB2
Entrez ID		7294	51096
HPRD ID		02505	10825
Ensembl ID		ENSG00000074966	ENSG00000011260
Uniprot IDs		P42681	Q9Y5J1
PDB IDs		2DM0
Enriched GO Terms of Interacting Partners?
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