TNFRSF4 and RC3H1

Data Source:
BioGRID (unspecified method)

		TNFRSF4	RC3H1
Description		TNF receptor superfamily member 4	ring finger and CCCH-type domains 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface	P-body Cytoplasmic Stress Granule
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding	RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding MiRNA Binding RNA Stem-loop Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell	Protein Polyubiquitination Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process B Cell Homeostasis Regulation Of Germinal Center Formation Negative Regulation Of Germinal Center Formation Ubiquitin-dependent Protein Catabolic Process Posttranscriptional Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation P-body Assembly T Cell Proliferation T Cell Homeostasis Regulation Of MRNA Stability Negative Regulation Of T-helper Cell Differentiation Negative Regulation Of Activated T Cell Proliferation Lymph Node Development Spleen Development T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization T Follicular Helper Cell Differentiation Cellular Response To Interleukin-1 Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of MiRNA Metabolic Process
Pathways		TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Interacting Genes		10 interacting genes: NUFIP2 RC3H1 SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5	14 interacting genes: ICOS TNF TNFRSF4 UBE2A UBE2B UBE2D2 UBE2F UBE2G1 UBE2G2 UBE2L3 UBE2N UBE2V1 UBE2V2 UCP3
Entrez ID		7293	149041
HPRD ID		02636	13913
Ensembl ID		ENSG00000186827	ENSG00000135870
Uniprot IDs		P43489	B7ZMB3 B9EGU6 Q5TC82
PDB IDs		1D0A 2HEV 2HEY 6OGX 6OKM 6OKN	3X1O 4QIK 4QIL 4ULW 4YWQ
Enriched GO Terms of Interacting Partners?
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