RC3H1 and TNFRSF4

Data Source:
BioGRID (unspecified method)

		RC3H1	TNFRSF4
Description		ring finger and CCCH-type domains 1	TNF receptor superfamily member 4
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GO Annotations	Cellular Component	P-body Cytoplasmic Stress Granule	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface
	Molecular Function	RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding MiRNA Binding RNA Stem-loop Binding Ubiquitin Protein Ligase Activity	Virus Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding
	Biological Process	Protein Polyubiquitination Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process B Cell Homeostasis Regulation Of Germinal Center Formation Negative Regulation Of Germinal Center Formation Ubiquitin-dependent Protein Catabolic Process Posttranscriptional Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation P-body Assembly T Cell Proliferation T Cell Homeostasis Regulation Of MRNA Stability Negative Regulation Of T-helper Cell Differentiation Negative Regulation Of Activated T Cell Proliferation Lymph Node Development Spleen Development T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization T Follicular Helper Cell Differentiation Cellular Response To Interleukin-1 Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of MiRNA Metabolic Process	Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell
Pathways			TNFs bind their physiological receptors
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Interacting Genes		14 interacting genes: ICOS TNF TNFRSF4 UBE2A UBE2B UBE2D2 UBE2F UBE2G1 UBE2G2 UBE2L3 UBE2N UBE2V1 UBE2V2 UCP3	10 interacting genes: NUFIP2 RC3H1 SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5
Entrez ID		149041	7293
HPRD ID		13913	02636
Ensembl ID		ENSG00000135870	ENSG00000186827
Uniprot IDs		B7ZMB3 B9EGU6 Q5TC82	P43489
PDB IDs		3X1O 4QIK 4QIL 4ULW 4YWQ	1D0A 2HEV 2HEY 6OGX 6OKM 6OKN
Enriched GO Terms of Interacting Partners?
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