TUBG1 and RPGR

Data Source:
HPRD (in vivo)

		TUBG1	RPGR
Description		tubulin gamma 1	retinitis pigmentosa GTPase regulator
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome Gamma-tubulin Complex Nucleus Cytoplasm Centrosome Spindle Polar Microtubule Cytosol Microtubule Recycling Endosome Mitotic Spindle Microtubule	Photoreceptor Outer Segment Golgi Apparatus Centrosome Ciliary Basal Body Sperm Flagellum
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Identical Protein Binding	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Nucleation Mitotic Spindle Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasmic Microtubule Organization Ciliary Basal Body-plasma Membrane Docking	Intracellular Protein Transport Visual Perception Intraciliary Transport Regulation Of Catalytic Activity Response To Stimulus Cilium Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		Vinblastine
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Retinitis pigmentosa (RP)
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		28 interacting genes: APP BRCA1 CENPJ CNTN2 CUL4A DDX41 IKBKG KIF14 KRT18 KRT19 MARK4 NAPG NDE1 PCNT PIK3R1 PLK1 PXN RACGAP1 RACK1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4	14 interacting genes: DCTN1 DCTN2 HOMEZ IFT88 KIF3A KIFAP3 NPM1 PDE6D RPGRIP1 SLC25A10 SMC1A SMC3 TUBG1 YWHAE
Entrez ID		7283	6103
HPRD ID		01853	02425
Ensembl ID		ENSG00000131462	ENSG00000156313
Uniprot IDs		P23258	Q92834
PDB IDs		1Z5V 1Z5W 3CB2 6V5V 6V6S	4JHN 4JHP 4QAM
Enriched GO Terms of Interacting Partners?
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