C4BPA and PROS1

Data Source:
HPRD (in vitro, in vivo)

		C4BPA	PROS1
Description		complement component 4 binding protein alpha	protein S
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Blood Microparticle	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	RNA Binding Protein Binding	Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding
	Biological Process	Complement Activation, Classical Pathway Response To Symbiotic Bacterium Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Opsonization	Platelet Degranulation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Leukocyte Migration
Pathways		Regulation of Complement cascade	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Drotrecogin alfa Menadione Sodium tetradecyl sulfate Kappadione
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency	Inherited thrombophilia
GWAS		Blood protein levels ( 29875488) C4b binding protein levels ( 20212171) Mean platelet volume ( 32888494 27863252) Platelet distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Venous thromboembolism ( 31420334 31676865)	Systemic lupus erythematosus ( 28714469)
Interacting Genes		9 interacting genes: APCS BMPR2 FXYD6 GIT2 GTF2I LBP LRP1 PROS1 SMARCD1	10 interacting genes: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3
Entrez ID		722	5627
HPRD ID		00403	01473
Ensembl ID		ENSG00000123838	ENSG00000184500
Uniprot IDs		P04003	A0A0S2Z4K3 A0A0S2Z4L3 P07225
PDB IDs		2A55 4B0F 5HYP 5HYT 5HYU 5HZP 5I0Q	1Z6C
Enriched GO Terms of Interacting Partners?
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