TRH and TRHR

Data Source:
HPRD (in vivo, in vitro)

		TRH	TRHR
Description		thyrotropin releasing hormone	thyrotropin releasing hormone receptor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Plasma Membrane Secretory Granule	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Thyrotropin-releasing Hormone Activity	Thyrotropin-releasing Hormone Receptor Activity Protein Binding
	Biological Process	Response To Hypoxia Histamine Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Cold Response To Glucose Hormone-mediated Signaling Pathway Negative Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Insulin Secretion Eating Behavior Response To Ethanol Response To Corticosterone Negative Regulation Of Feeding Behavior	G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs			Protirelin
Diseases
GWAS		Alzheimer's disease ( 30636644) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body mass (lean) ( 19268274) Daytime sleep phenotypes ( 27126917) LDL cholesterol levels ( 32203549) Night sleep phenotypes ( 27126917) Pulse pressure ( 30224653) Type 2 diabetes ( 30297969)
Interacting Genes		5 interacting genes: ARRB2 CPE KCNIP4 LCN2 TRHR	19 interacting genes: ARRB1 C1QL4 COMT EFNA5 FAM241B FXYD6-FXYD2 GJB2 IER3IP1 NIPAL4 PEDS1-UBE2V1 SLC39A2 SLC39A9 SLC41A1 TMEFF2 TMEM218 TMEM239 TRH UBE2J1 YIPF6
Entrez ID		7200	7201
HPRD ID		08944	11767
Ensembl ID		ENSG00000170893	ENSG00000174417
Uniprot IDs		P20396	P34981
PDB IDs
Enriched GO Terms of Interacting Partners?
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